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1. WO2000012492 - BENZOXAZINE DERIVATIVES

Publication Number WO/2000/012492
Publication Date 09.03.2000
International Application No. PCT/JP1999/004631
International Filing Date 27.08.1999
Chapter 2 Demand Filed 26.02.2000
IPC
C07D 265/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
34condensed with carbocyclic rings
36condensed with one six-membered ring
C07D 413/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 265/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
34condensed with carbocyclic rings
36condensed with one six-membered ring
C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • NISSAN CHEMICAL INDUSTRIES, LTD. [JP]/[JP] (AllExceptUS)
  • TANIKAWA, Keizo [JP]/[JP] (UsOnly)
  • OHRAI, Kazuhiko [JP]/[JP] (UsOnly)
  • SATO, Masayuki [JP]/[JP] (UsOnly)
  • YANAGIHARA, Kazufumi [JP]/[JP] (UsOnly)
  • SHIGETA, Yukihiro [JP]/[JP] (UsOnly)
  • YAMASHITA, Toru [JP]/[JP] (UsOnly)
Inventors
  • TANIKAWA, Keizo
  • OHRAI, Kazuhiko
  • SATO, Masayuki
  • YANAGIHARA, Kazufumi
  • SHIGETA, Yukihiro
  • YAMASHITA, Toru
Agents
  • HANABUSA, Tsuneo
Priority Data
10-24675901.09.1998JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BENZOXAZINE DERIVATIVES
(FR) DERIVES DE BENZOXAZINE
Abstract
(EN)
Benzoxazine derivative of the formula (I) in which, R1 is hydrogen, or a substituent, R2 and R3 each independently are hydrogen or C1-6 alkyl, R4 is C1-6 alkyl, C3-6 cycloalkyl, phenyl, C(=Y1)Z1R8 or C(=Y1)R8, n is 0 or an integer of 1 to four, W is C=O or -CH2-, X is -CONH-, -CH2NH-, -NHCONH- or -SO2NH-, Y is substituted or unsubstituted aryl or heterocyclyl and pharmaceutically acceptable salts thereof are useful as active ingredients for pharmaceutical compositions for curing cardiac insufficiency.
(FR)
L'invention porte sur des dérivés de benzoxazine de la formule (I) (dans laquelle R1 est un hydrogène ou un substituant; R2 et R3 sont chacun, indépendamment, un hydrogène ou un C1-6 alkyl ; R4 est un C1-6 alkyl, C3-6 cycloalkyl, phényle, C(=Y1)Z1R8 ou C(=Y1)R8, n est 0 ou un entier compris entre 1 et 4, W est C=O ou -H2-, X est -ONH-, -CH2NH-, -NHCONH- ou -SO2NH-, Y est un aryle ou hétérocyclyle substitué ou non substitué. L'invention porte également sur des sels pharmaceutiquement acceptables de ces dérivés qui sont utiles comme ingrédients actifs dans des compositions pharmaceutiques destinées à traiter l'insuffisance cardiaque.
Also published as
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