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1. WO2000012146 - GELS AND MULTILAYER SURFACE STRUCTURES FROM BORONIC ACID CONTAINING POLYMERS

Publication Number WO/2000/012146
Publication Date 09.03.2000
International Application No. PCT/US1999/019633
International Filing Date 27.08.1999
Chapter 2 Demand Filed 23.03.2000
IPC
A61L 27/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 29/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
29Materials for catheters or for coating catheters
08Materials for coatings
A61L 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
08Materials for coatings
10Macromolecular materials
CPC
A61L 27/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 29/085
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
29Materials for catheters, ; medical tubing, cannulae, or endoscopes; or for coating catheters
08Materials for coatings
085Macromolecular materials
A61L 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
08Materials for coatings
10Macromolecular materials
Applicants
  • EIDGENÖSSISCH TECHNISCHE HOCHSCHULE ZURICH [CH]/[CH]
  • HUBBELL, Jeffrey, A. [US]/[CH]
Inventors
  • HUBBELL, Jeffrey, A.
  • ELBERT, Donald, L.
  • WINBLADE, Natalie, D.
Agents
  • PABST, Patrea, L.
Priority Data
60/098,04027.08.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GELS AND MULTILAYER SURFACE STRUCTURES FROM BORONIC ACID CONTAINING POLYMERS
(FR) PREPARATION DE GELS ET DE STRUCTURES DE SURFACE MULTICOUCHES AVEC DES POLYMERES RENFERMANT DE L'ACIDE BORIQUE
Abstract
(EN)
Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form cross-linked hydrogels, which are highly swollen in water. The cross-linking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically cross-linked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues $i(in situ), decreasing the incidence or severity of such pathologic conditions as the formation of post-surgical adhesions, and thrombosis following angioplasty.
(FR)
La présente invention concerne des polymères renfermant de l'acide borique utilisés pour préparer des gels et des structures de surfaces multicouches bio-inertes. Ces polymères forment des hydrogels réticulés qui gonflent fortement dans l'eau, la réticulation pouvant être chimique ou physique. En outre, on peut réticuler physiquement les polymères hydrosolubles renfermant des groupes d'acide borique, notamment l'acide phénylborique (PBA), en mélangeant ces polymères dans l'eau avec d'autres polymères renfermant des hydroxyles ou des acides carboxyliques. Dans une variante, on peut traiter ces surfaces par incubation par paliers avec une solution du polymère renfermant l'acide borique, suivie par une incubation avec une solution de polymère renfermant un diol ou un acide carboxylique. En l'occurrence, on peut produire plusieurs couches successives, de manière à épaissir la structure formée à chaque étape. Par ailleurs, on peut utiliser le gel ou le revêtement de surface bio-inerte pour passiver les surfaces des implants médicaux (en particulier ceux disposés sur des tissus greffés), ou pour passiver les surfaces des tissus $i(in situ), de manière à réduire l'occurrence ou la gravité d'états pathologiques, comme par exemple la formation d'adhérences post-chirurgicales, et la thrombose suivant l'angioplastie.
Also published as
NZ510057
Latest bibliographic data on file with the International Bureau