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1. WO2000011027 - METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS USING PEPTIDE ANALOGS OF HUMAN MYELIN BASIC PROTEIN

Publication Number WO/2000/011027
Publication Date 02.03.2000
International Application No. PCT/US1999/019033
International Filing Date 19.08.1999
Chapter 2 Demand Filed 20.03.2000
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/4713
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4713Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
Applicants
  • NOVARTIS AG [CH]/[CH]
  • NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH [AT]/[AT]
  • NEUROCRINE BIOSCIENCES, INC. [US]/[US]
Inventors
  • GAUR, Amitabh
  • CONLON, Paul
  • LING, Nicholas, C.
  • STAEHLIN, Theophil
  • CROWE, Paul
Agents
  • KADLECEK, Ann, T.
  • GOWSHALL, Jonathan, V.
Priority Data
09/137,75920.08.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS USING PEPTIDE ANALOGS OF HUMAN MYELIN BASIC PROTEIN
(FR) TRAITEMENTS DE LA SCLEROSE EN PLAQUES AU MOYEN D'ANALOGUES PEPTIDIQUES DE LA PROTEINE DE BASE DE LA MYELINE HUMAINE
Abstract
(EN)
The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95 or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.
(FR)
L'invention concerne les analogues peptidiques de la protéine de base de la myéline humaine. Cet analogue peptidique a une longueur d'au moins sept acides aminés et est dérivé des résidus 83 à 99 de la protéine de base de la myéline humaine. Ces analogues sont modifiés par rapport à la séquence d'origine au moins aux positions 91, 95 ou 97. D'autres modifications peuvent être effectuées en d'autres positions. L'invention concerne également des compositions pharmaceutiques contenant ces analogues peptidiques. Ces analogues peptidiques sont utiles pour le traitement de la sclérose en plaque.
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