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1. WO1999060383 - IMPROVED PHASE ANGLE AND MODULATION OF FLUORESCENT ASSAY

Considered void:  22.11.2000
Publication Number WO/1999/060383
Publication Date 25.11.1999
International Application No. PCT/US1999/010874
International Filing Date 17.05.1999
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
G01N 21/6408
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6408with measurement of decay time, time resolved fluorescence
Applicants
  • FLUORRX, INC. [US]/[US]
  • SZMACINSKI, Henryk [PL]/[US] (UsOnly)
Inventors
  • SZMACINSKI, Henryk
Agents
  • KENEMORE, Max
Priority Data
60/085,54515.05.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED PHASE ANGLE AND MODULATION OF FLUORESCENT ASSAY
(FR) AMELIORATION DE L'ANGLE DE PHASE ET DE LA MODULATION EN ANALYSE FLUORIMETRIQUE
Abstract
(EN)
The presence or concentration of analytes in a sample can be assayed by observing with fluorescent lifetime techniques such as phase angle shift and modulation change the combined response to excitation of a fluorescent probe in the presence of the sample and a fluorescent material, the probe having a fluorescence intensity response to the presence or concentration of the analyte, the probe and the material having no substantial fluorescence lifetime change in response to the presence or concentration of the analyte and the material having a fluorescence lifetime in response to excitation that is different from the fluorescence lifetime of the probe.
(FR)
Il est possible d'analyser la présence ou la concentration d'analysats dans un échantillon en observant, avec des techniques liées à la durée de vie de la fluorescence (par exemple, modification de l'angle de phase et changement de modulation), la réponse combinée à l'excitation d'une sonde fluorescente en présence de l'échantillon et d'un matériau fluorescent, sachant que la sonde présente une certaine réponse d'intensité de fluorescence devant une présence ou une concentration d'anlysat, et que, par ailleurs, la sonde et le matériau ne manifestent pas de changement substantiel quant à la durée de vie de la fluorescence en réponse à une présence ou une concentration d'analysat, et que le matériau possède en réponse à l'excitation une durée de vie de fluorescence qui diffère de celle de la sonde.
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