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1. WO1999059562 - METHOD OF TREATING OR PREVENTING ABNORMAL CARDIAC CELL GROWTH BY INHIBITING THE 12-LIPOXYGENASE PATHWAY

Publication Number WO/1999/059562
Publication Date 25.11.1999
International Application No. PCT/US1999/011115
International Filing Date 20.05.1999
Chapter 2 Demand Filed 15.11.1999
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
04Nitro compounds
A61K 31/045 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/05 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/201 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
201having one or two double bonds, e.g. oleic or linoleic acid
A61K 31/275 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
275Nitriles; Isonitriles
CPC
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
04Nitro compounds
A61K 31/045
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/201
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
201having one or two double bonds, e.g. oleic, linoleic acids
A61K 31/275
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
275Nitriles; Isonitriles
Applicants
  • CITY OF HOPE [US]/[US]
Inventors
  • NADLER, Jerry, L.
  • WEN, Yeshao
Agents
  • CASSIDY, Martha
Priority Data
60/086,14720.05.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF TREATING OR PREVENTING ABNORMAL CARDIAC CELL GROWTH BY INHIBITING THE 12-LIPOXYGENASE PATHWAY
(FR) METHODE DE TRAITEMENT OU DE PREVENTION D'UNE CROISSANCE CELLULAIRE CARDIAQUE ANORMALE PAR INHIBITION DU CHEMIN DE LA 12-LIPOXYGENASE
Abstract
(EN)
The present invention is directed toward a method of treating or inhibiting abnormal cardiac growth. Specifically, the invention involves inhibition of the 12-lipoxygenase pathway or action of the 12-lipoxygenase products, to reduce or eliminate 12-lipoxygenase pathway mediated cardiac hypertrophic effects at a cellular level. Useful compounds are selected from the group consisting of pioglitazone, panaxynol, phenidone, baicalein, and cinnamyl1-3,4-dihydroxy-a-cyanocinnamate, 13(S)-hydroxyoctadecadienoic acid, 2-phenylmethyl-1-naphthol(DuP654), 2-N-butyl-4-cholo-5-hydroxymethyl1-1-[2'-(1H-tetrazol-5-zl)biphenyl-4-yl)methyl] imidazole (Losartan), pertussis toxin, 12(S)-HETE analogs, peptides and peptide analogs having affinity for the binding site on the 23(S)-HETE receptors and antibodies to the 12(S)-HETE receptor.
(FR)
L'invention concerne une méthode de traitement ou d'inhibition d'une croissance cardiaque anormale. Notamment, l'invention concerne l'inhibition du mécanisme d'action de la 12-lipoxygénase ou de l'action de produits à base de 12-lipoxygénase, de manière à réduire ou éliminer les effets d'hypertrophie cardiaque induits par le mécanisme d'action de la 12-lipoxygénase au niveau cellulaire.
Also published as
Latest bibliographic data on file with the International Bureau