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1. WO1999058569 - PLASMIN INHIBITORS FROM THE AUSTRALIAN BROWN SNAKE $i(PSEUDONAJA TEXTILIS TEXTILIS)

Publication Number WO/1999/058569
Publication Date 18.11.1999
International Application No. PCT/AU1999/000343
International Filing Date 07.05.1999
Chapter 2 Demand Filed 24.11.1999
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 14/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
CPC
A61K 47/6811
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
6811the drug being a protein or peptide, e.g. transferrin or bleomycin
A61K 47/6843
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6843the antibody targeting a material from animals or humans
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
C07K 14/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
Applicants
  • THE UNIVERSITY OF QUEENSLAND [AU]/[AU] (AllExceptUS)
  • NATIONAL INSTITUTE OF BIOLOGICAL STANDARDS AND CONTROL, UNITED KINGDOM [GB]/[GB] (AllExceptUS)
  • MASCI, Pantaleone, Paul [AU]/[AU] (UsOnly)
  • LAVIN, Martin, Francis [AU]/[AU] (UsOnly)
  • GAFFNEY, Patrick, Joseph [GB]/[GB] (UsOnly)
Inventors
  • MASCI, Pantaleone, Paul
  • LAVIN, Martin, Francis
  • GAFFNEY, Patrick, Joseph
Agents
  • FISHER ADAMS KELLY
Priority Data
PP 345011.05.1998AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PLASMIN INHIBITORS FROM THE AUSTRALIAN BROWN SNAKE $i(PSEUDONAJA TEXTILIS TEXTILIS)
(FR) INHIBITEURS DE PLASMINE TIRES DU SERPENT BRUN AUSTRALIEN $i(PSEUDONAJA TEXTILIS TEXTILIS)
Abstract
(EN)
The invention provides novel single stage competitive inhibitors of plasmin from the Australian brown snake $i(Pseudonaja textilis textilis). The invention also features polynucleotides and polynucleotide homologues encoding these inhibitors. Pharmaceutical compositions containing the plasmin inhibitors of the invention are also disclosed as well as methods useful for treatment of blood loss.
(FR)
Cette invention a trait à de nouveaux inhibiteurs compétitifs, à stade unique, de la plasmine, tirés du serpent brun australien $i(Pseudonaja textilis textilis). Elle porte également sur des polynucléotides et des homologues de polynucléotide codant ces inhibiteurs. Elle concerne, en outre, des compositions pharmaceutiques contenant ces inhibiteurs de plasmine ainsi que des méthodes efficaces de traitement de la perte sanguine.
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