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1. WO1999055902 - DIAGNOSTIC MARKERS OF HUMAN FEMALE INFERTILITY

Publication Number WO/1999/055902
Publication Date 04.11.1999
International Application No. PCT/US1999/009366
International Filing Date 29.04.1999
Chapter 2 Demand Filed 21.10.1999
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
G01N 2333/495
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
475Assays involving growth factors
495Transforming growth factor [TGF]
G01N 2800/361
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
36Gynecology or obstetrics
361Menstrual abnormalities or abnormal uterine bleeding, e.g. dysmenorrhea
G01N 2800/367
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
36Gynecology or obstetrics
367Infertility, e.g. sperm disorder, ovulatory dysfunction
Applicants
  • UNIVERSITY OF SOUTH FLORIDA [US]/[US] (AllExceptUS)
  • TABIBZADEH, Siamak [US]/[US] (UsOnly)
Inventors
  • TABIBZADEH, Siamak
Agents
  • KOHN, Kenneth
Priority Data
60/083,41829.04.1998US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIAGNOSTIC MARKERS OF HUMAN FEMALE INFERTILITY
(FR) MARQUEURS DIAGNOSTIQUES DE L'INFERTILITE CHEZ LA FEMME
Abstract
(EN)
There is provided a method for diagnosing endometrial irregularites particularly infertility by screening an endometrial sample or bodily fluid for the presence of ebaf. Also provided is a diagnostic tool for determining the presence of endometrial irregularities screens a sample for the presence of ebaf. A contraceptive containing an effective amount of ebaf and a pharmaceutically acceptable carrier is also provided. Additionally, a diagnostic kit for timing conception is provided having a screening tool for screening a sample for the present of ebaf. Also provided is a method of treating endometrial irregularities by down-regulating the expression of ebaf.
(FR)
L'invention concerne un procédé permettant de diagnostiquer des irrégularités endométriales et notamment l'infertilité par le criblage d'un échantillon endométrial ou d'un liquide biologique à la recherche du facteur EBAF. L'invention concerne aussi un outil diagnostique pour déterminer la présence d'irrégularités endométriales qui permet le criblage d'un échantillon à la recherche du facteur EBAF. De plus, l'invention concerne un contraceptif contenant une quantité efficace de facteur EBAF et un excipient pharmaceutiquement acceptable ainsi qu'un kit de diagnostic permettant de planifier la conception, qui contient un outil permettant le criblage d'un échantillon à la recherche du facteur EBAF. L'invention concerne enfin un procédé pour traiter les irrégularités endométriales par la rétro-régulation de l'expression du facteur EBAF.
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