Processing

Please wait...

Settings

Settings

Goto Application

1. WO1999054440 - CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF

Publication Number WO/1999/054440
Publication Date 28.10.1999
International Application No. PCT/EP1999/002693
International Filing Date 21.04.1999
Chapter 2 Demand Filed 22.11.1999
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
Applicants
  • MICROMET GESELLSCHAFT FÜR BIOMEDIZINISCHE FORSCHUNG MBH [DE]/[DE] (AllExceptUS)
  • DÖRKEN, Bernd [DE]/[DE] (UsOnly)
  • RIETHMÜLLER, Gert [DE]/[DE] (UsOnly)
  • KUFER, Peter [DE]/[DE] (UsOnly)
  • LUTTERBÜSE, Ralf [DE]/[DE] (UsOnly)
  • BARGOU, Ralf [DE]/[DE] (UsOnly)
  • LÖFFLER, Anja [DE]/[DE] (UsOnly)
Inventors
  • DÖRKEN, Bernd
  • RIETHMÜLLER, Gert
  • KUFER, Peter
  • LUTTERBÜSE, Ralf
  • BARGOU, Ralf
  • LÖFFLER, Anja
Agents
  • VOSSIUS & PARTNER
Priority Data
98107269.721.04.1998EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF
(FR) POLYPEPTIDES SPECIFIQUES A CD19 ET CD3 ET LEURS UTILISATIONS
Abstract
(EN) Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above-described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described, In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.
(FR) L'invention concerne de nouveaux polypeptides multifonctionnels à une chaîne, comprenant au moins deux sites de liaison respectivement spécifiques aux antigènes CD19 et CD3. L'invention concerne également des polypeptides dans lesquels les polypeptides susmentionnés renferment au moins un domaine supplémentaire, de préférence d'une fonction prédéfinie. L'invention concerne en outre les polynucléotides codant pour ces polypeptides, les vecteurs comprenant ces polynucléotides et les cellules hôtes transformées à l'aide de ces polynucléotides, ainsi que leur utilisation dans la production desdits polypeptides. Cette invention concerne par ailleurs des compositions, de préférence pharmaceutiques et diagnostiques, renfermant l'un des polypeptides, polynucléotides, ou vecteurs susmentionnés. L'invention concerne enfin l'utilisation des polypeptides, polynucléotides, ou vecteurs susmentionnés pour préparer des compositions pharmaceutiques destinées à être utilisées en immunothérapie, de préférence contre les cellules B malignes, par exemple le lymphome non hodgkinien.
Related patent documents
ININ/PCT/2000/544/CHEThis application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
HRP20000714AThis application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
TR2000/03087This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
ZA200005866This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
NO20005296This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
Latest bibliographic data on file with the International Bureau