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1. (WO1999051188) A POLYPEPTIDE COMPRISING THE AMINO ACID OF AN N-TERMINAL CHOLINE BINDING PROTEIN A TRUNCATE, VACCINE DERIVED THEREFROM AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1999/051188 International Application No.: PCT/US1999/007669
Publication Date: 14.10.1999 International Filing Date: 07.04.1999
Chapter 2 Demand Filed: 05.11.1999
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/315 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
315
from Streptococcus (G), e.g. Enterococci
Applicants:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US/US]; 332 North Lauderdale Street Memphis, TN 38105-2794, US (AllExceptUS)
MEDIMMUNE, INC. [US/US]; 35 West Watkins Mill Road Gaithersburg, MD 20878, US (AllExceptUS)
TUOMANEN, Elaine, I. [US/US]; US (UsOnly)
MASURE, H., Robert [US/US]; US (UsOnly)
WIZEMANN, Theresa, M. [US/US]; US (UsOnly)
JOHNSON, Leslie, Sydnor [US/US]; US (UsOnly)
KOENIG, Scott [US/US]; US (UsOnly)
Inventors:
TUOMANEN, Elaine, I.; US
MASURE, H., Robert; US
WIZEMANN, Theresa, M.; US
JOHNSON, Leslie, Sydnor; US
KOENIG, Scott; US
Agent:
JACKSON, David, A. ; Klauber & Jackson 411 Hackensack Avenue Hackensack, NJ 07601, US
Priority Data:
09/056,01907.04.1998US
60/080,87807.04.1998US
Title (EN) A POLYPEPTIDE COMPRISING THE AMINO ACID OF AN N-TERMINAL CHOLINE BINDING PROTEIN A TRUNCATE, VACCINE DERIVED THEREFROM AND USES THEREOF
(FR) POLYPEPTIDE COMPRENANT L'ACIDE AMINE D'UN PRODUIT TRONQUE DE LA PROTEINE A N-TERMINALE FIXANT LA CHOLINE, VACCIN DERIVE DE CE POLYPEPTIDE ET SES UTILISATIONS
Abstract:
(EN) This invention provides an isolated polypeptide comprising an amino acid sequence of an N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1,3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides isolated polypeptides comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of an N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of an N-terminal choline binding protein A truncate. This invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of N-terminal choline binding protein A truncate. Lastly, this invention provides pharmaceutical compositions, vaccines, and diagnostic and therapeutic methods of use.
(FR) L'invention concerne un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, laquelle séquence apparaît dans SEQ ID NOS: 1, 3-7 ou 9-11, y compris les fragments, mutants, variants, analogues ou dérivés de ce polypeptide. L'invention concerne également un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, où l'acide aminé apparaît dans SEQ ID NO 2, où le polypeptide conserve sa structure tertiaire d'origine. L'invention concerne également les méthodes d'élaboration de ce polypeptide. L'invention concerne également un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, où le polypeptide présente une activité de lectine et ne fixe pas la choline. L'invention concerne également un polypeptide isolé immunogène comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline. L'invention concerne également un acide nucléique isolé codant un polypeptide comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline. Enfin, l'invention concerne des compositions pharmaceutiques, des vaccins et des méthodes diagnostiques et thérapeutiques d'utilisation de ces compositions et de ces vaccins.
Designated States: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV2000-3803NO20005081TR2000/03498TR2003/01629MXPA/a/2000/009899KR1020010052244
ZA2000/06309IL138939JP4739521 JP2002516662 CN1342088CA2326388
NZ507983AU1999034797