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Machine translation
1. (WO1999042604) METHODS OF SCREENING COMPOUNDS FOR BIOACTIVITY IN ORGANIZED TISSUE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042604    International Application No.:    PCT/US1999/003459
Publication Date: 26.08.1999 International Filing Date: 18.02.1999
Chapter 2 Demand Filed:    17.08.1999    
IPC:
G01N 33/50 (2006.01)
Applicants: CELL BASED DELIVERY [US/US]; 275 Westminster Street Providence, RI 02903 (US)
Inventors: VANDENBURGH, Herman, H.; (US).
VALENTINI, Robert, F.; (US)
Agent: WILLIAMS, Kathleen, M.; Banner & Witcoff, Ltd. 28 State Street Boston, MA 02109 (US)
Priority Data:
60/075,054 18.02.1998 US
60/086,370 22.05.1998 US
Title (EN) METHODS OF SCREENING COMPOUNDS FOR BIOACTIVITY IN ORGANIZED TISSUE
(FR) PROCEDES DE CRIBLAGE DE COMPOSES DESTINES A RECHERCHER UNE BIOACTIVITE DANS UN TISSU STRUCTURE
Abstract: front page image
(EN)The invention provides a method of screening a compound for bioactivity, comprising contacting a candidate bioactive compound with an organized tissue, and measuring in at least a cell of the organized tissue a biological parameter that is associated with bioactivity, wherein a change in the biological parameter that occurs as a result of the contacting step is indicative of bioactivity of the candidate compound.
(FR)L'invention concerne un procédé de criblage d'un composé pour rechercher une bioactivité. Le procédé consiste à placer un composé bioactif candidat au contact d'un tissu structuré, à mesurer dans au moins une cellule du tissu structuré un paramètre biologique associé à la bioactivité. Un changement intervenant dans le paramètre biologique à la suite de l'étape précédente indique une bioactivité du composé candidat.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)