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1. (WO1999042602) FERMENTATIVE PREPARATION PROCESS FOR CYTOSTATICS AND CRYSTAL FORMS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042602    International Application No.:    PCT/EP1999/001025
Publication Date: 26.08.1999 International Filing Date: 17.02.1999
Chapter 2 Demand Filed:    20.07.1999    
IPC:
C07D 493/04 (2006.01), C12P 17/16 (2006.01), C12P 17/18 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Schwarzwaldallee 215, CH-4058 Basel (CH) (AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH [AT/AT]; Brunner Strasse 59, A-1235 Vienna (AT) (AT only)
Inventors: HOFMANN, Hans; (CH).
MAHNKE, Marion; (DE).
MEMMERT, Klaus; (DE).
PETERSEN, Frank; (DE).
SCHUPP, Thomas; (CH).
KÜSTERS, Ernst; (DE).
MUTZ, Michael; (DE)
Agent: BECKER, Konrad; Novartis AG, Corporate Intellectual Property, Patent & Trademark Dept., CH-4002 Basel (CH)
Priority Data:
396/98 19.02.1998 CH
1007/98 05.05.1998 CH
Title (EN) FERMENTATIVE PREPARATION PROCESS FOR CYTOSTATICS AND CRYSTAL FORMS THEREOF
(FR) PROCEDE DE PREPARATION PAR FERMENTATION DE CYTOSTATIQUES ET DE FORMES CRISTALLINES
Abstract: front page image
(EN)The invention relates to a process for concentrating epothilones in culture media, a process for the production of epothilones, a process for separating epothilones A and B and a strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. Crystal forms of epothilone B are also described.
(FR)L'invention concerne un procédé permettant de concentrer des épothilones dans un milieu de culture, un procédé destiné à produire des épothilones, un procédé visant à séparer des épothilones A et B, et une souche obtenue par mutagenèse, conçue pour produire des épothilones. L'invention concerne également différents aspects liés à ces procédés, ainsi que des formes cristallines d'épothilone B.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)