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1. (WO1999042590) METHOD FOR PRODUCING TRIFLUORO-3(R)-HYDROXYBUTYRIC ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042590    International Application No.:    PCT/EP1999/001017
Publication Date: 26.08.1999 International Filing Date: 18.02.1999
Chapter 2 Demand Filed:    13.08.1999    
IPC:
C12N 9/02 (2006.01), C12N 9/04 (2006.01), C12P 7/42 (2006.01), C12P 7/62 (2006.01), C12P 11/00 (2006.01), C12P 13/02 (2006.01)
Applicants: LONZA AG [CH/CH]; (Geschäftsleitung: 4002 Basel), CH-3945 Gampel (CH) (For All Designated States Except US).
PETERSEN, Michael [DE/CH]; (CH) (For US Only).
BIRCH, Olwen [GB/CH]; (CH) (For US Only).
SHIMIZU, Sakayu [JP/JP]; (JP) (For US Only).
KIENER, Andreas [CH/CH]; (CH) (For US Only).
HISCHIER, Marie-Luise [CH/CH]; (CH) (For US Only).
THÖNI, Susanne [CH/CH]; (CH) (For US Only)
Inventors: PETERSEN, Michael; (CH).
BIRCH, Olwen; (CH).
SHIMIZU, Sakayu; (JP).
KIENER, Andreas; (CH).
HISCHIER, Marie-Luise; (CH).
THÖNI, Susanne; (CH)
Agent: RITTHALER, Wolfgang; Winter, Brandl & Partner, Alois-Steinecker-Strasse 22, D-85354 Freising (DE)
Priority Data:
388/98 18.02.1998 CH
Title (DE) VERFAHREN ZUR HERSTELLUNG VON TRIFLUOR-3(R)-HYDROXYBUTTERSÄUREDERIVATEN
(EN) METHOD FOR PRODUCING TRIFLUORO-3(R)-HYDROXYBUTYRIC ACID DERIVATIVES
(FR) PROCEDE POUR LA PREPARATION DE DERIVES D'ACIDE TRIFLUOR-3(R)-HYDROXYBUTYRIQUE
Abstract: front page image
(DE)Beschrieben wird ein biotechnologisches Verfahren zur Herstellung von Trifluor-3(R)-hydroxybuttersäurederivaten der allgemeinen Formel (I), worin R?1¿-OR?2¿, worin R?2¿ Wasserstoff, C¿1-10?-Alkyl, C¿1-10?-Alkenyl, C¿3-8? Cycloalkyl, Aryl, Alkoxyalkyl oder Alkoxyalkoxyalkyl ist, -NR?3¿R?4¿, worin R?3¿ und R?4¿ gleich oder verschieden sind und für Wasserstoff, C¿1-10?-Alkyl, C¿1-10?-Alkenyl, C¿3-8?-Cycloalkyl oder Aryl stehen, oder -SR?5¿, worin R?5¿ Wasserstoff, C¿1-10?-Alkyl, C¿1-10?-Alkenyl, Aryl oder C¿3-8?-Cycloalkyl ist, bedeutet, ausgehend von einem Trifluoracetessigsäurederivat der allgemeinen Formel (II), worin R?1¿ die genannte Bedeutung hat, mittels Mikroorganismen, die befähigt sind, eine Carbonylfunktion zu reduzieren oder mittels einem zellfreien Enzymextrakt dieser Mikroorganismen.
(EN)The invention relates to a biotechnological method for producing trifluoro-3(R)-hydroxybutyric acid derivatives of the general formula (I), where R?1¿ represents -OR?2¿, where R?2¿ is hydrogen, C¿1-10? alkyl, C¿1-10? alkenyl, C¿3-8? cycloalkyl, aryl, alkoxyalkyl or alkoxyalkoxyalkyl; -NR?3¿R?4¿, where R?3¿ and R?4¿ are the same or different and represent hydrogen, C¿1-10? alkyl, C¿1-10? alkenyl, C¿3-8? cycloalkyl or aryl; or -SR?5¿, where R?5¿ represents hydrogen, C¿1-10? alkyl, C¿1-10? alkenyl, aryl or C¿3-8? cycloalkyl, based on a trifluoroacetoacetic acid derivative of the general formula (II), where R?1¿ has the meaning given above, by means of micro-organisms which are able to reduce a carbonyl function or by means of a cell-free enzyme extract of said micro-organisms.
(FR)L'invention concerne un procédé biotechnologique pour la préparation de dérivés d'acide trifluor-3-(R)-hydroxybutyrique de la formule générale (I), dans laquelle R?1¿ représente -OR?2¿ où R?2¿ est hydrogène, alkyle C¿1-10?, alcényle C¿1-10?, cycloalkyle C¿3-8?, aryle, alcoxyalkyle ou bien alcoxyalcoxyalkyle; -NR?3¿R?4¿ où R?3¿ et R?4¿ sont identiques ou différents et représentent hydrogène, alkyle C¿1-10?, alcényle C¿1-10?, cycloalkyle C¿3-8? ou bien aryle; ou encore -SR?5¿ où R?5¿ représente hydrogène, alkyle C¿1-10?, alcényle C¿1-10?, aryle ou bien cycloalkyle C¿3-8?, à partir d'un dérivé d'acide trifluoroacétylacétique de la formule générale (II), dans laquelle R?1¿ a la signification donnée, au moyen de micro-organismes, qui sont aptes à réduire une fonction carbonyle, ou bien au moyen d'un extrait enzymatique acellulaire de ces micro-organismes.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)