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Machine translation
1. (WO1999042480) ANALGESIC PEPTIDES FROM VENOM OF $i(GRAMMOSTOLA SPATULATA) AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042480    International Application No.:    PCT/GB1998/000534
Publication Date: 26.08.1999 International Filing Date: 20.02.1998
Chapter 2 Demand Filed:    23.08.1999    
IPC:
A61K 38/00 (2006.01), C07K 14/435 (2006.01)
Applicants: ZENECA LIMITED [GB/GB]; 15 Stanhope Gate London W1Y 6LN (GB)
Inventors: LAMPE, Richard, Alexander; (US)
Agent: BILL, Kevin; Zeneca Pharmaceuticals Intellectual Property Dept. Mereside, Alderley Park Macclesfield Cheshire SK10 4TG (GB)
Priority Data:
Title (EN) ANALGESIC PEPTIDES FROM VENOM OF $i(GRAMMOSTOLA SPATULATA) AND USE THEREOF
(FR) PEPTIDES ANALGESIQUES EXTRAITS DU VENIN DE LA $i(GRAMMOSTOLA SPATULATA) ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence Tyr-Cys-Gln- Lys-Trp-Leu- Trp-Thr-Cys-Asp- Ser-Glu-Arg-Lys- Cys-Cys-Glu- Asp-Met-Val- Cys-Arg-Leu- Trp-Cys-Lys- Lys-Arg-Leu-NH2 (SEQ ID NO:1) or Tyr-Cys-Gln- Lys-Trp-Met- Trp-Thr-Cys- Asp-Glu-Glu- Arg-Lys-Cys- Cys-Glu-Gly- Leu-Val-Cys- Arg-Leu -Trp-Cys-Lys-Lys- Lys-Ile-Glu-Trp (SEQ ID NO:2). The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO:1. The peptides of SEQ ID NO:1 and SEQ ID NO:2 can also be used in methods for identifying compounds having analgesia-inducing activity.
(FR)L'invention porte sur de nouvelles méthodes de traitement de la douleur consistant à administrer à un mammifère le nécessitant une dose à effet analgésique d'un peptide présentant soit la séquence d'acides aminés: Tyr-Cys-Gln-Lys-Trp-Leu-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Arg-Leu-NH2 (SEQ ID NO:1), soit la séquence d'acides aminés: Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Glu-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Leu-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Ile-Glu-Trp (SEQ ID NO:2. L'invention porte également sur un peptide purifié présentant la séquence d'acides aminés SEQ ID NO:1. Les peptides des séquences SEQ ID NO:1 et SEQ ID NO:2 peuvent de plus être utilisés dans des méthodes d'identification de composés analgésiogènes.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)