WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1999042461) SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

IA Considered Withdrawn 2000-05-13 00:00:00.0


Pub. No.:    WO/1999/042461    International Application No.:    PCT/US1998/026707
Publication Date: 26.08.1999 International Filing Date: 15.12.1998
IPC:
C07D 241/44 (2006.01), C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 403/04 (2006.01), C07D 405/04 (2006.01), C07D 409/04 (2006.01), C07D 409/14 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), C07D 417/04 (2006.01), C07D 453/02 (2006.01), C07D 521/00 (2006.01)
Applicants: WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950 (US) (For All Designated States Except US).
CONNOR, David, Thomas [GB/US]; (US) (For US Only).
LI, Jie, Jack [US/US]; (US) (For US Only).
LOW, Joseph, Edwin [--/US]; (US) (For US Only).
MILLER, Steven, Robert [US/US]; (US) (For US Only).
ROTH, Bruce, David [US/US]; (US) (For US Only).
TRIVEDI, Bharat, Kalidas [IN/US]; (US) (For US Only)
Inventors: CONNOR, David, Thomas; (US).
LI, Jie, Jack; (US).
LOW, Joseph, Edwin; (US).
MILLER, Steven, Robert; (US).
ROTH, Bruce, David; (US).
TRIVEDI, Bharat, Kalidas; (US)
Agent: RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 (US)
Priority Data:
60/075,551 23.02.1998 US
Title (EN) SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS
(FR) DERIVES DE QUINOXALINE SUBSTITUES UTILISES COMME ANTAGONISTES DU RECEPTEUR DE L'INTERLEUKINE-8
Abstract: front page image
(EN)Quinoxaline compounds are described as well as method for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in the treatment of a chemokine-mediated disease wherein the chemokine binds to an IL-8a (CXCR1) or b (CXCR2) receptor such as, a chemokine-mediated disease selected from psoriasis, or atopic dermatitis, disease associated with pathological angiogenesis (i.e. cancer), asthma, chronic obstructive pulmonary disease, adult respiratory distress syndrome, arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, gastric ulcer, septic shock, endotoxic shock, gram-negative sepsis, toxic shock syndrome, stroke, cardiac and renal reperfusion injury, glomerulo-nephritis, or thrombosis, Alzheimer's disease, graft versus host reaction, or allograft rejections.
(FR)Cette invention se rapporte à des composés de quinoxaline, ainsi qu'à des procédés de préparation de ces composés et à des compositions pharmaceutiques contenant ces composés, qui servent comme antagonistes du récepteur de l'interleukine-8 (IL-8) et qui peuvent être utilisés dans le traitement des maladies induites par la chémokine, dans lesquelles la chémokine se fixe à un récepteur d'IL-8a (CXCR1) ou b (CXCR2), telles que des maladies induites par la chémokine choisies parmi le psoriasis ou la dermatite atopique, les maladies associées à une angiogenèse pathologique (par exemple le cancer), l'asthme, les broncho-pneumopathies chroniques obstructives, le syndrome de détresse respiratoire chez l'adulte, l'arthrite, les infections intestinales inflammatoires, la maladie de Crohn, la colite ulcéreuse, l'ulcère gastrique, le choc septique, le choc endotoxique, les septicémies à germes Gram négatif, le syndrome du choc toxique staphylococcique, les attaques, les lésions de reperfusion cardiaque et rénale, la glomérulonéphrite ou les thromboses, la maladie d'Alzheimer, les réactions du greffon contre l'hôte ou les rejets d'allogreffes.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, HR, HU, ID, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)