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1. (WO1999042456) NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042456    International Application No.:    PCT/DK1999/000070
Publication Date: 26.08.1999 International Filing Date: 18.02.1999
Chapter 2 Demand Filed:    01.09.1999    
IPC:
C07D 239/90 (2006.01), C07D 285/24 (2006.01), C07D 285/28 (2006.01), C07D 417/04 (2006.01), C07D 513/04 (2006.01)
Applicants: NEUROSEARCH A/S [DK/DK]; Pederstrupvej 93, DK-2750 Ballerup (DK) (For All Designated States Except US).
GOULIAEV, Alex, Haahr [DK/DK]; (DK) (For US Only).
LARSEN, Mogens [DK/DK]; (DK) (For US Only).
VARMING, Thomas [DK/DK]; (DK) (For US Only).
MATHIESEN, Claus [DK/DK]; (DK) (For US Only).
JOHANSEN, Tina, Holm [DK/DK]; (DK) (For US Only).
SCHEEL-KRÜGER, Jørgen [DK/DK]; (DK) (For US Only).
OLSEN, Gunnar, M. [DK/DK]; (DK) (For US Only).
NIELSEN, Elsebet, Østergaard [DK/DK]; (DK) (For US Only)
Inventors: GOULIAEV, Alex, Haahr; (DK).
LARSEN, Mogens; (DK).
VARMING, Thomas; (DK).
MATHIESEN, Claus; (DK).
JOHANSEN, Tina, Holm; (DK).
SCHEEL-KRÜGER, Jørgen; (DK).
OLSEN, Gunnar, M.; (DK).
NIELSEN, Elsebet, Østergaard; (DK)
Common
Representative:
NEUROSEARCH A/S; Patent Dept., Pederstrupvej 93, DK-2750 Ballerup (DK)
Priority Data:
0226/98 18.02.1998 DK
Title (EN) NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS
(FR) NOUVEAUX COMPOSES ET LEUR UTILISATION COMME MODULATEURS POSITIFS DU RECEPTEUR AMPA
Abstract: front page image
(EN)The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R?2¿; X represents SO¿2? or C=O of CH¿2?; Y represents -CH(R?4¿)-, -N(R?4¿)- or -N(R?4¿)-CH¿2?-, O; and the meaning of R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, and R?8¿ are as defined in the application. The compounds are useful as positive modulators of the AMPA-receptor.
(FR)La présente invention concerne de nouveaux composés représentés par la formule générale (I) où la liaison représentée par le pointillé peut être une liaison simple ou double ou être absente, auquel cas l'azote est substitué par un hydrogène et R?2¿. X est SO¿2? ou C=O de CH¿2?. Y est -CH(R?4¿)-, -N(R?4¿)- ou -N(R?4¿)-CH¿2?-, O. En outre, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ sont conformes à la définition qui en est donnée dans la description. Ces composés conviennent comme modulateurs positifs du récepteur AMPA.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)