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1. (WO1999042451) BENZIMIDAZOLE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042451    International Application No.:    PCT/JP1999/000794
Publication Date: 26.08.1999 International Filing Date: 23.02.1999
Chapter 2 Demand Filed:    16.09.1999    
IPC:
C07D 235/26 (2006.01), C07D 235/30 (2006.01)
Applicants: KUREHA CHEMICAL INDUSTRY CO., LTD. [JP/JP]; 9-11, Nihonbashihoridome-cho 1-chome Chuo-ku Tokyo 103-8552 (JP) (For All Designated States Except US).
YANAKA, Mikiro [JP/JP]; (JP) (For US Only).
SUZUKI, Shigeru [JP/JP]; (JP) (For US Only).
NISHIJIMA, Fuyuhiko [JP/JP]; (JP) (For US Only).
TAKAHASHI, Hiroshi [JP/JP]; (JP) (For US Only).
SUGANO, Mikio [JP/JP]; (JP) (For US Only).
MARUOKA, Hiroshi [JP/JP]; (JP) (For US Only).
YAMAZAKI, Toru [JP/JP]; (JP) (For US Only).
DEWA, Toshikazu [JP/JP]; (JP) (For US Only).
ENARI, Hiroyuki [JP/JP]; (JP) (For US Only).
ISE, Michihito [JP/JP]; (JP) (For US Only)
Inventors: YANAKA, Mikiro; (JP).
SUZUKI, Shigeru; (JP).
NISHIJIMA, Fuyuhiko; (JP).
TAKAHASHI, Hiroshi; (JP).
SUGANO, Mikio; (JP).
MARUOKA, Hiroshi; (JP).
YAMAZAKI, Toru; (JP).
DEWA, Toshikazu; (JP).
ENARI, Hiroyuki; (JP).
ISE, Michihito; (JP)
Agent: MORITA, Kenichi; 5th floor, Itabashi-chuo Building 67-8, Itabashi 2-chome Itabashi-ku Tokyo 173-0004 (JP)
Priority Data:
10/57497 23.02.1998 JP
Title (EN) BENZIMIDAZOLE DERIVATIVE
(FR) DERIVE DU BENZIMIDAZOLE
Abstract: front page image
(EN)A novel benzimidazole derivative [specifically, for example, 2-ethoxy-1-[{4'-(2''-N,N-dimethylamino-ethoxycarbonyl)phenyl}methyl]-1H-benzimidazole-6-carboxylic acid morpholide] represented by formula (I) and a salt thereof. The compound exhibits satisfactory curative and preventive effects for cardiac and nephric diseases, although it has little action to blood-pressure.
(FR)Nouveau dérivé du benzimidazole (plus précisément, par exemple, le morpholide de l'acide 2-éthoxy-1-[(4'-(2''-N,N-diméthylamino-éthoxycarbonyl)phényl)méthyl]-1H-benzimidazole-6-carboxylique), représenté par la formule (I), et sel dudit dérivé. Ce composé possède une activité thérapeutique et préventive satisfaisante dans les maladies cardiaques et rénales, bien qu'il ait peu d'effet sur la pression artérielle.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)