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1. (WO1999042442) AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042442    International Application No.:    PCT/JP1999/000703
Publication Date: 26.08.1999 International Filing Date: 18.02.1999
Chapter 2 Demand Filed:    15.03.1999    
IPC:
C07D 209/06 (2006.01), C07D 209/88 (2006.01), C07D 215/38 (2006.01), C07D 215/60 (2006.01), C07D 221/04 (2006.01), C07D 231/56 (2006.01), C07D 237/28 (2006.01), C07D 239/74 (2006.01), C07D 261/20 (2006.01), C07D 307/79 (2006.01), C07D 307/84 (2006.01), C07D 401/04 (2006.01), C07D 405/04 (2006.01), C07D 409/04 (2006.01), C07D 417/04 (2006.01)
Applicants: TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 1-1, Doshomashi 4-chome Chuo-ku Osaka-shi Osaka 541-0045 (JP) (For All Designated States Except US).
SHIRAISHI, Mitsuru [JP/JP]; (JP) (For US Only).
FUKUMOTO, Shoji [JP/JP]; (JP) (For US Only).
KUSUMOTO, Keiji [JP/JP]; (JP) (For US Only)
Inventors: SHIRAISHI, Mitsuru; (JP).
FUKUMOTO, Shoji; (JP).
KUSUMOTO, Keiji; (JP)
Agent: ASAHINA, Tadao; Osaka Plant of Takeda Chemical Industries, Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku Osaka-shi Osaka 532-0024 (JP)
Priority Data:
10/38720 20.02.1998 JP
10/298383 20.10.1998 JP
Title (EN) AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF
(FR) DERIVES D'AMINOGUANIDINE HYDRAZONE, PROCEDES DE PRODUCTION, ET MEDICAMENTS A BASE DE CES DERIVES
Abstract: front page image
(EN)Compounds represented by general formula (I) or salts thereof having preventive and therapeutic effects on ischemic heart diseases, etc., and being useful as preventives/remedies for ischemic heart diseases such as heart infarction and arrhythmia. In formula (I), A represents optionally substituted 5- or 6-membered heteroaryl; B represents an optionally substituted 5- or 6-membered aromatic homocycle or heterocycle; R?1¿ represents hydrogen, hydroxy or lower alkyl; and n is 0 or 1.
(FR)L'invention concerne des composés représentés par la formule générale (I) ci-après ou des sels de ces composés, lesquels composés ont des effets préventifs et thérapeutiques sur les cardiopathies ischémiques, etc. et sont utilisés comme agents prophylactiques/remèdes pour les cardiopathies ischémiques telles que l'infarctus du myocarde et l'arhythmie. Dans la formule (I), A représente un hétéroaryle à 5 ou 6 éléments éventuellement substitué; B représente un homocycle ou un hétérocycle à 5 ou 6 éléments éventuellement substitué; R?1¿ représente hydrogène, un hydroxy ou un alkyle inférieur; et n est égal à 0 ou 1.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GD, GE, HR, HU, ID, IL, IN, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, SL, TJ, TM, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)