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Machine translation
1. (WO1999042138) THE USE OF BJERKNES FORCES TO MANIPULATE CONTRAST AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/042138    International Application No.:    PCT/US1999/003358
Publication Date: 26.08.1999 International Filing Date: 17.02.1999
Chapter 2 Demand Filed:    14.09.1999    
IPC:
A61K 47/48 (2006.01), A61K 48/00 (2006.01), C12N 15/87 (2006.01)
Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION [US/US]; 1224 West Main Street #1-110 Charlottesville, VA 22903 (US) (For All Designated States Except US).
FERRARA, Katherine, W. [US/US]; (US) (For US Only).
DAYTON, Paul [US/US]; (US) (For US Only).
GOODE, Allen [US/US]; (US) (For US Only)
Inventors: FERRARA, Katherine, W.; (US).
DAYTON, Paul; (US).
GOODE, Allen; (US)
Agent: REPPER, George, R.; Rothwell, Figg, Ernst & Kurz Suite 701 East 555 13th Street N.W. Columbia Square Washington, DC 20004 (US)
Priority Data:
60/075,147 19.02.1998 US
Title (EN) THE USE OF BJERKNES FORCES TO MANIPULATE CONTRAST AGENTS
(FR) UTILISATION DES FORCES DE BJERKNES POUR MANIPULER DES PRODUITS DE CONTRASTE
Abstract: front page image
(EN)Microbubbles used for contrast-assisted imaging can be manipulated by taking advantage of both primary and secondary Bjerknes forces. The primary Bjerknes force allows microbubbles to be pushed away from the inducing pressure of the ultrasound. This can be used to push microbubbles against a desired target such as a tissue wall to which they can bind. Advantage is made of the secondary Bjerknes forces which results in microbubbles forming aggregates. The positioning of these aggregates can be manipulated and can result in an improved ultrasound image. Manipulation of drug-filled microbubbles using the primary and secondary forces, especially in combination with a pulse of ultrasound to destroy the microbubbles, allows for targeted drug delivery.
(FR)L'invention concerne des micro-bulles utilisées pour l'imagerie à l'aide de produits de contraste qui peuvent être gérées en utilisant les forces de Bjerknes primaires et secondaires. Ces forces de Bjerknes primaires permettent de pousser les microbulles à l'aide de la pression d'induction des ultrasons. Cela permet de pousser les microbulles contre une cible requise telle qu'une paroi tissulaire sur laquelle elles peuvent se fixer. Les forces de Bjerknes secondaires permettent de former des agrégats à partir des microbulles. Le positionnement de ces agrégats peut être géré et peut améliorer l'image ultrasonore. La manipulation de microbulles remplies de médicaments à l'aide des forces primaires et secondaires, en particulier, en association avec une impulsion ultrasonore pour détruire les microbulles, permet d'assurer l'administration ciblée du médicament.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)