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1. (WO1999042087) CONTROLLED RELEASE POTASSIUM CHLORIDE PELLET BASED PHARMACEUTICAL COMPOSITIONS HAVING A HIGH ACTIVE INGREDIENT CONTENT

Pub. No.:    WO/1999/042087    International Application No.:    PCT/HU1999/000013
Publication Date: Aug 26, 1999 International Filing Date: Feb 19, 1999
IPC: A61K 9/20
A61K 9/50
A61K 33/08
Applicants: EGIS GYÓGYSZERGYÁR RT.
NAGY, Tibor
PATAKI, Károly
GÜNTHER, Gábor
FEKETE, Pál
FARAGÓ, Gábor
LADY, Blanka
Inventors: NAGY, Tibor
PATAKI, Károly
GÜNTHER, Gábor
FEKETE, Pál
FARAGÓ, Gábor
LADY, Blanka
Title: CONTROLLED RELEASE POTASSIUM CHLORIDE PELLET BASED PHARMACEUTICAL COMPOSITIONS HAVING A HIGH ACTIVE INGREDIENT CONTENT
Abstract:
The invention relates to controlled release multi-dosage pharmaceutical composition in solid oral form, preferably in the form of tablets or hard gelatine capsules and having a potassium chloride content of 500-1000 mg per dosage unit characterized by a content of at least 70 % by weight of potassium chloride, in the form of coated or partially uncoated pellets. The tablets or hard gelatine capsules according to the present invention are comprising pellets which contain at least 70 % by weight of potassium chloride, 10-25 % by weight of microcrystalline cellulose, 0.1-0.5 % by weight of an anti-adhesion agent and 0.1-5.0 % by weight of a hydrophobizing agent; a coating layer applied onto said pellets comprising 3-10 % by weight of an ethyl acrylate/methyl methacrylate copolymer and/or an ammonium methacrylate copolymer, a hydrophobizing agent, talc and optionally a dye; and optionally potassium chloride particles and further auxiliary agents applied onto said layer.