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Machine translation
1. (WO1999041612) METHODS AND COMPOSITIONS FOR DIAGNOSIS OF HEPATOMA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/041612    International Application No.:    PCT/GB1999/000458
Publication Date: 19.08.1999 International Filing Date: 15.02.1999
Chapter 2 Demand Filed:    13.09.1999    
IPC:
C07K 14/47 (2006.01), C07K 16/18 (2006.01), G01N 33/574 (2006.01)
Applicants: OXFORD GLYCOSCIENCES (UK) LTD. [GB/GB]; 10 The Quadrant Barton Lane Abingdon Science Park Abingdon Oxon OX14 3YS (GB) (For All Designated States Except US).
PAREKH, Rajesh, Bhikhu [GB/GB]; (GB) (For US Only).
PATEL, Thakorbhai, Parshotambhai [GB/GB]; (GB) (For US Only).
TOWNSEND, Robert, Reid [US/GB]; (GB) (For US Only).
MOYSES, Christopher [GB/GB]; (GB) (For US Only).
JOHNSON, Philip, J. [GB/CN]; (CN) (For US Only)
Inventors: PAREKH, Rajesh, Bhikhu; (GB).
PATEL, Thakorbhai, Parshotambhai; (GB).
TOWNSEND, Robert, Reid; (GB).
MOYSES, Christopher; (GB).
JOHNSON, Philip, J.; (CN)
Agent: CHAPMAN, Paul, William; Kilburn & Strode 20 Red Lion Street London WC1R 4PJ (GB)
Priority Data:
9803138.8 13.02.1998 GB
9803269.1 16.02.1998 GB
Title (EN) METHODS AND COMPOSITIONS FOR DIAGNOSIS OF HEPATOMA
(FR) PROCEDES ET COMPOSITIONS DE DIAGNOSTIC DU CARCINOME HEPATOCELLULAIRE
Abstract: front page image
(EN)The present invention provides methods and compositions for screening, diagnosis and prognosis of hepatoma, for monitoring the effectiveness of hepatoma treatment, and for drug development. Hepatoma-Diagnostic Features (HFs), detectable by two-dimensional electrophoresis of serum or plasma are described. The invention further provides Hepatoma-Diagnostic Protein Isoforms (HPIs) detectable in serum or plasma, preparations comprising isolated HPIs, antibodies immunospecific for HPIs, and kits comprising the aforesaid.
(FR)L'invention concerne des procédés et des compositions permettant de rechercher, de diagnostiquer un carcinome hépatocellulaire et d'établir un pronostic pour ce dernier, de vérifier l'efficacité d'un traitement du carcinome hépatocellulaire, et mettre au point des médicaments. L'invention concerne également des caractères pathognomoniques du carcinome hépatocelluaire qui peuvent être détectés par une électrophorèse bidimensionnelle du sérum ou du plasma. L'invention concerne en outre des isoformes de protéines pour le diagnostic du carcinome hépatocellulaire (HPI: Hepatoma-Diagnostic Protein Isoforms) détectables dans le sérum ou le plasma, des préparation contenant les HPI isolés, des anticorps pour les HPI immunospécifiques, et des ensembles comprenant ces différents éléments.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)