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Machine translation
1. (WO1999041400) METHODS FOR PSEUDOADENOVIRAL VECTOR PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/041400    International Application No.:    PCT/US1999/003483
Publication Date: 19.08.1999 International Filing Date: 17.02.1999
Chapter 2 Demand Filed:    07.09.1999    
IPC:
C12N 15/861 (2006.01)
Applicants: GENZYME CORPORATION [US/US]; 15 Pleasant Street Connector P.O. Box 9322 Framingham, MA 01701-9322 (US) (For All Designated States Except US).
WADSWORTH, Samuel, C. [US/US]; (US) (For US Only).
ROMANCZUK, Helen [US/US]; (US) (For US Only).
GREGORY, Richard, J. [US/US]; (US) (For US Only).
ARMENTANO, Donna [US/US]; (US) (For US Only)
Inventors: WADSWORTH, Samuel, C.; (US).
ROMANCZUK, Helen; (US).
GREGORY, Richard, J.; (US).
ARMENTANO, Donna; (US)
Agent: LAZAR, Steven R.; MetroWest Place 15 Pleasant Street Connector P.O. Box 9322, Framingham Massachusetts 01701 (US)
Priority Data:
60/074,761 17.02.1998 US
60/086,528 22.05.1998 US
Title (EN) METHODS FOR PSEUDOADENOVIRAL VECTOR PRODUCTION
(FR) PROCEDES DE FABRICATION DE VECTEURS PSEUDO-ADENOVIRAUX
Abstract: front page image
(EN)The invention is directed to helper adenoviruses which facilitate the production of pseudoadenoviral vectors (PAV) but which cannot be packaged into viral particles. The invention is further directed to novel PAV producer cell lines expressing DNA binding and/or repressor proteins that prevent the packaging of the helper viruses. The invention is also directed to methods for the production of PAV in such cell lines with minimal contamination from helper viruses.
(FR)L'invention concerne des adénovirus auxiliaires qui facilitent la production de vecteurs pseudo-adénoviraux (PAV) mais qui ne peuvent pas être encapsidés dans des particules virales. L'invention concerne également de nouvelles lignées cellulaires de production de PAV qui expriment les protéines liantes ou les répresseurs des ADN empêchant l'encapsidation des adénovirus auxiliaires. En outre, l'invention concerne des procédés de fabrication de PAV dans ces lignées cellulaires avec un minimum de contamination due aux virus auxiliaires.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)