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Machine translation
1. (WO1999041398) VECTORS, CELLS AND METHODS FOR THE PRODUCTION OF DELETERIOUS VIRAL EUKARYOTIC GENE TRANSFER VECTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/041398    International Application No.:    PCT/US1999/002889
Publication Date: 19.08.1999 International Filing Date: 11.02.1999
Chapter 2 Demand Filed:    09.08.1999    
IPC:
C07K 14/47 (2006.01), C12N 9/02 (2006.01), C12N 15/861 (2006.01)
Applicants: GENVEC, INC. [US/US]; 65 West Watkins Mill Road Gaithersburg, MD 20878 (US) (For All Designated States Except US).
BRUDER, Joseph, T. [US/US]; (US) (For US Only).
KOVESDI, Imre [US/US]; (US) (For US Only).
LIZONOVA, Alena [SK/US]; (US) (For US Only)
Inventors: BRUDER, Joseph, T.; (US).
KOVESDI, Imre; (US).
LIZONOVA, Alena; (US)
Agent: LARCHER, Carol; Leydig, Voit & Mayer, Ltd. Suite 4900 Two Prudential Plaza 180 North Stetson Chicago, IL 60601-6780 (US)
Priority Data:
60/074,372 11.02.1998 US
Title (EN) VECTORS, CELLS AND METHODS FOR THE PRODUCTION OF DELETERIOUS VIRAL EUKARYOTIC GENE TRANSFER VECTORS
(FR) VECTEURS, CELLULES ET PROCEDES DE PRODUCTION DE VECTEURS DE TRANSFERT DE GENES EUCARYOTES, VIRAUX ET DELETERES
Abstract: front page image
(EN)The present invention provides a method of $i(in vitro) propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
(FR)La présente invention concerne un procédé de propagation $i(in vitro) d'un vecteur de transfert génique eucaryote viral comprenant un gène délétère, c'est-à-dire cytostatique, cytotoxique, ou apoptotique dans une cellule hôte eucaryote, par exemple, une cellule de mammifère, comprenant un gène bloquant. Ce gène bloquant inhibe les effets indésirables du gène délétère sur la cellule hôte eucaryote. L'invention concerne également des vecteurs et des cellules utiles dans le cadre du procédé de la présente invention.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)