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1. (WO1999041376) RETINOBLASTOMA PROTEIN COMPLEXES AND RETINOBLASTOMA INTERACTING PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/041376    International Application No.:    PCT/US1999/003072
Publication Date: 19.08.1999 International Filing Date: 12.02.1999
Chapter 2 Demand Filed:    10.09.1999    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/47 (2006.01)
Applicants: CURAGEN CORPORATION [US/US]; 11th floor 555 Long Wharf Drive New Haven, CT 06511 (US) (For All Designated States Except US).
YANG, Meijia [CN/US]; (US) (For US Only).
NANDABALAN, Krishnan [IN/US]; (US) (For US Only).
SCHULZ, Vincent, Peter [US/US]; (US) (For US Only)
Inventors: YANG, Meijia; (US).
NANDABALAN, Krishnan; (US).
SCHULZ, Vincent, Peter; (US)
Agent: ELRIFI, Ivor, R.; Mintz, Levin, Cohn, Ferris, Glovsky, and Popeo, P.C. One Financial Center Boston, MA 02111 (US)
Priority Data:
60/074,559 12.02.1998 US
09/248,960 11.02.1999 US
Title (EN) RETINOBLASTOMA PROTEIN COMPLEXES AND RETINOBLASTOMA INTERACTING PROTEINS
(FR) COMPLEXES PROTEIQUES DE RETINOBLASTOME ET PROTEINES INTERAGISSANT AVEC LE RETINOBLASTOME
Abstract: front page image
(EN)The present invention relates to complexes of the retinoblastoma (RB) protein with proteins identified as interacting with RB by an improved, modified yeast two hybrid assay system. The proteins identified to interact with RB are RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392*. Thus, the present invention provides complexes of RB and RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392* and derivatives, fragments and analogs thereof. The invention also provides the $i(CD24*), $i(Set*), $i(GluT1*), and $i(115392*) genes and proteins and derivatives, fragments and analogs thereof. Methods of screening the complexes for efficacy in treating and/of preventing certain diseases and disorders, particularly hyperproliferative disorders, including cancer, neurodegenerative disease, and viral disease, are also disclosed herein.
(FR)La présente invention concerne des complexes de la protéine du rétinoblastome (RB) avec des protéines identifiées comme interagissant avec RB par un système amélioré de criblage à deux hybrides de levures modifiés. Les protéines identifiées comme devant interagir avec RB sont RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophiline A, Zap 3, CD24*, Set*, GluT1* et 115392*. Ainsi, l'invention présente concerne des complexes de RB et de RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), la cyclophiline A, Zap 3, CD24*, Set*, GluT1* et 115392* ainsi que des dérivés, fragments et analogues desdits composés. L'invention concerne également les gènes et protéines $i(CD24*), $i(Set*), $i(GluT1*) et $i(115392*) ainsi que des dérivés, fragments et analogues de ces composés. L'invention a également trait à des techniques de criblage de complexes visant à améliorer l'efficacité du traitement et/ou de la prévention de certaines maladies et troubles, notamment de pathologies hyperprolifératives dont le cancer, les maladies neurodégénératives et les maladies virales.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)