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Machine translation
1. (WO1999041285) TREATING AND DIAGNOSING MACROPHAGE-MEDIATED DISEASES USING FC RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/041285    International Application No.:    PCT/US1999/003488
Publication Date: 19.08.1999 International Filing Date: 17.02.1999
Chapter 2 Demand Filed:    15.09.1999    
IPC:
A61K 38/00 (2006.01), A61K 47/48 (2006.01), C07K 16/28 (2006.01), G01N 33/50 (2006.01), G01N 33/68 (2006.01)
Applicants: MEDAREX, INC. [US/US]; 1545 Route 22 East P.O. Box 953 Annandale, NJ 08801-0953 (US)
Inventors: VAN DE WINKEL, Jan, G., J.; (NL)
Agent: DECONTI, Giulio, A., Jr.; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109 (US)
Priority Data:
60/074,967 17.02.1998 US
Title (EN) TREATING AND DIAGNOSING MACROPHAGE-MEDIATED DISEASES USING FC RECEPTOR LIGANDS
(FR) TRAITEMENT ET DIAGNOSTIC DES MALADIES DUES AUX MACROPHAGES AU MOYEN DES LIGANDS DES RECEPTEURS DE FC
Abstract: front page image
(EN)The invention provides methods and compositions for selectively targeting macrophages in a localized area. The compositions of the invention include an Fc receptor binding agent, and a toxic or a detectable agent. Methods for depleting or inhibiting the activity of macrophages using the compositions of the invention are disclosed. The compositions of the invention can be used therapeutically and diagnostically.
(FR)L'invention concerne des procédés et des compositions pour choisir de manière sélective des macrophages dans une zone localisée. Les compositions de cette invention comprennent un agent liant les récepteurs de Fc et un agent toxique ou détectable. L'invention concerne des procédés pour affaiblir ou freiner l'activité des macrophages au moyen des compositions ci-décrites. Les compositions de cette invention peuvent s'utiliser dans la thérapie et le diagnostic.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)