WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1999040944) HYDROXYLATION ACTIVATED DRUG RELEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/040944    International Application No.:    PCT/GB1999/000416
Publication Date: 19.08.1999 International Filing Date: 10.02.1999
Chapter 2 Demand Filed:    08.09.1999    
IPC:
A46B 9/04 (2006.01), A61K 31/27 (2006.01), A61K 31/337 (2006.01), A61K 31/37 (2006.01), A61K 31/505 (2006.01), A61K 31/513 (2006.01), A61K 31/535 (2006.01), A61K 31/536 (2006.01), A61K 31/565 (2006.01), A61K 31/70 (2006.01), A61K 31/704 (2006.01), A61K 47/48 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), G07F 17/30 (2006.01)
Applicants: DE MONTFORT UNIVERSITY [GB/GB]; The Gateway, Leicester, Leicestershire LE1 9BH (GB) (For All Designated States Except US).
POTTER, Gerard, Andrew [GB/GB]; (GB) (For US Only).
PATTERSON, Lawrence, Hylton [GB/GB]; (GB) (For US Only).
BURKE, Michael, Danny [GB/GB]; (GB) (For US Only)
Inventors: POTTER, Gerard, Andrew; (GB).
PATTERSON, Lawrence, Hylton; (GB).
BURKE, Michael, Danny; (GB)
Agent: LLOYD WISE, McNEIGHT & LAWRENCE; c/o Commonwealth House, 1-19 New Oxford Street, London WC1A 1LW (GB)
Priority Data:
9802957.2 12.02.1998 GB
09/115.016 14.07.1998 US
Title (EN) HYDROXYLATION ACTIVATED DRUG RELEASE
(FR) LIBERATION DE MEDICAMENTS ACTIVEE PAR HYDROXYLATION
Abstract: front page image
(EN)The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumour prodrugs and those which are specifically activated by the hydroxylation activity of the P-450 enzyme CYP1B1. Also provided are methods of detection of aromatic oxidation activity.
(FR)L'invention concerne des promédicaments dont l'oxydation aromatique, en particulier, l'hydroxylation aromatique, enzymatique, produit leur activation par libération d'une fraction de médicament. L'invention concerne, en particulier, des promédicaments antitumoraux ainsi que ceux activés, de manière spécifique, par l'activité d'hydroxylation de l'enzyme CYP1B1 de P-450. L'invention concerne également des techniques de détection d'activité d'oxydation aromatique.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)