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1. (WO1999040932) MIXED MICELLAR PHARMACEUTICAL DELIVERY SYSTEM AND METHOD OF PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/040932    International Application No.:    PCT/CA1999/000106
Publication Date: 19.08.1999 International Filing Date: 05.02.1999
Chapter 2 Demand Filed:    22.07.1999    
IPC:
A61K 9/107 (2006.01), A61K 9/127 (2006.01), A61K 38/28 (2006.01)
Applicants: GENEREX PHARMACEUTICALS, INC. [CA/CA]; 202, 33 Harbour Square, Toronto, Ontario M5J 2G2 (CA) (For All Designated States Except US).
MODI, Pankaj [CA/CA]; (CA) (For US Only)
Inventors: MODI, Pankaj; (CA)
Agent: BARRIGAR & MOSS; Suite 901, 2 Robert Speck Parkway, Mississauga, Ontario L4Z 1H8 (CA)
Priority Data:
09/021,114 10.02.1998 US
09/216,733 21.12.1998 US
Title (EN) MIXED MICELLAR PHARMACEUTICAL DELIVERY SYSTEM AND METHOD OF PREPARATION
(FR) SYSTEME ET METHODE D'ADMINISTRATION DE PRODUIT PHARMACEUTIQUE MICELLAIRE MELANGE
Abstract: front page image
(EN)A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal C8 to C22 alkyl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. The amount of each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt.% of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt.% of the formulation.
(FR)Une formulation pharmaceutique micellaire mélangée contient un agent pharmaceutique protéique micellaire, un sulfate d'alkyle C8 à C22 de métal alcalin, un salicylate de métal alcalin, un édétate pharmaceutiquement acceptable et au moins un composé favorisant l'absorption, choisi dans le groupe constitué de lécithine, d'acide hyaluronique, de sels pharmaceutiquement acceptables d'acide hyaluronique, d'octylphénoxypolyéthoxyéthanol, d'acide glycolique, d'acide lactique, d'extrait de camomille, d'extrait de concombre, d'acide oléique, d'acide linoléique, d'huile de bourrache, d'huile d'onagre, de trihydroxy-oxo-cholanylglycine, de glycérine, de polyglycérine, de lysine, de polylysine, de trioléine et de mélanges de ceux-ci. La proportion de chaque composé favorisant l'absorption est de 1 à 10 % en poids du poids total de la formulation, et la concentration totale de composés favorisant l'absorption est inférieure à 50 % en poids du poids total de la formulation.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)