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1. (WO1999040931) CYCLIC DIPEPTIDES AND AZETIDINONE COMPOUNDS AND THEIR USE IN TREATING CNS INJURY AND NEURODEGENERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/040931    International Application No.:    PCT/US1999/003147
Publication Date: 19.08.1999 International Filing Date: 10.02.1999
Chapter 2 Demand Filed:    08.09.1999    
IPC:
C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 403/14 (2006.01), C07D 405/14 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07K 5/097 (2006.01)
Applicants: GEORGETOWN UNIVERSITY [US/US]; 37th & O Streets, N.W. Washington, DC 20057 (US)
Inventors: KOZIKOWSKI, Alan, P.; (US).
FADEN, Alan, I.; (US).
ARALDI, Gian, Luca; (US)
Agent: ABRAMS, Samuel, B.; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036 (US)
Priority Data:
09/022,184 11.02.1998 US
60/095,788 07.08.1998 US
09/246,307 08.02.1999 US
Title (EN) CYCLIC DIPEPTIDES AND AZETIDINONE COMPOUNDS AND THEIR USE IN TREATING CNS INJURY AND NEURODEGENERATIVE DISORDERS
(FR) DIPEPTIDES CYCLIQUES ET COMPOSES D'AZETIDINONE ET LEUR UTILISATION AFIN DE TRAITER DES LESIONS DU SYSTEME NERVEUX CENTRAL ET DES MALADIES NEURODEGENERATIVES
Abstract: front page image
(EN)The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.
(FR)L'invention concerne des composés de 4-substituée-2-azétidinone, des composés bicycliques de 2-5-dikétopipérazine et leurs compositions pharmaceutiques qui sont des agents neuroprotecteurs puissants, sans danger et efficaces. Etant donné leur activité puissante sur le système nerveux central (CNS), on peut utiliser ces composés afin d'améliorer la mémoire et de traiter une variété de maladies neurologiques. Ces composés sont particulièrement utiles pour traiter des maladies neurologiques provoquées par un traumatisme du système nerveux central ou associées à ce traumatisme.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)