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Machine translation
1. (WO1999040117) THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/040117    International Application No.:    PCT/IB1999/000367
Publication Date: 12.08.1999 International Filing Date: 04.02.1999
Chapter 2 Demand Filed:    16.08.1999    
IPC:
A61K 38/00 (2006.01), C07K 14/735 (2006.01)
Applicants: ILEXUS PTY. LIMITED [AU/AU]; c/o Austin Research Institute, Kronheimer Building, A & RMC, Studley Road, Heidelberg, VIC 3084 (AU)
Inventors: HOGARTH, P., Mark; (AU).
POWELL, Maree, S.; (AU).
MCKENZIE, Ian, F., C.; (AU).
MAXWELL, Kelly, F.; (AU).
GARRETT, Thomas, P., J.; (AU).
EPA, Vidana; (AU).
BAELL, Jonathan, B.; (AU).
MATTHEWS, Barry, R.; (AU).
MCCARTHY, Thomas, D.; (AU).
PIETERSZ, Geoffrey, A.; (AU)
Priority Data:
60/073,972 06.02.1998 US
60/099,994 11.09.1998 US
Title (EN) THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF
(FR) STRUCTURES TRIDIMENSIONNELLES ET MODELES DE RECEPTEURS Fc, ET LEURS UTILISATIONS
Abstract: front page image
(EN)Disclosed are crystals, crystal structure Fc$g(g)RIIa protein, three-dimensional coordinates of Fc$g(g)RIIa protein, and structures and models derived from the Fc$g(g)RIIa structure. Also disclosed are crystals of Fc$g(e)RI protein and three-dimensional coordinates of Fc$g(e)RI protein monomers and dimers derived from the Fc$g(g)RIIa structure. Also disclosed are three-dimensional coordinates of Fc$g(g)RIIIb proteins and models of Fc$g(g)RIIIb derived from the Fc$g(g)RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
(FR)L'invention concerne des cristaux, une protéine Fc$g(g)RIIa à structure cristalline, les coordonnées tridimensionnelles de la protéine Fc$g(g)RIIa, et des structures et des modèles dérivés de la structure de Fc$g(g)RIIa. L'invention concerne également des cristaux de protéine Fc$g(e)RI et les coordonnées tridimensionnelles de monomères et de dimères protéiniques Fc$g(e)RI dérivés de la structure Fc$g(g)RIIa, ainsi que les coordonnées tridimensionnelles de protéines Fc$g(g)RIIIb et des modèles de Fc$g(g)RIIIb dérivés de la structure de Fc$g(g)RIIa. La présente invention concerne enfin des méthodes permettant de produire ces cristaux et structures et modèles de cristaux, ainsi que les utilisations de ces cristaux, et structures et modèles de cristaux, notamment dans la mise au point de médicaments et de compositions thérapeutiques basés sur ces structures.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)