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1. (WO1999039763) ULTRASOUND-MEDIATED DRUG DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/039763    International Application No.:    PCT/US1999/002701
Publication Date: 12.08.1999 International Filing Date: 09.02.1999
Chapter 2 Demand Filed:    10.09.1999    
IPC:
A61B 17/00 (2006.01), A61M 37/00 (2006.01)
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 300 Longwood Avenue Boston, MA 02115 (US)
Inventors: ATALA, Anthony; (US).
MACHLOUF, Marcelle; (US)
Agent: HANLEY, Elizabeth, A.; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109 (US)
Priority Data:
60/074,231 10.02.1998 US
09/114,810 13.07.1998 US
Title (EN) ULTRASOUND-MEDIATED DRUG DELIVERY
(FR) ADMINISTRATION DE MEDICAMENTS PAR ULTRASONS
Abstract: front page image
(EN)Methods and apparatus are disclosed for treating physiological problems, and for providing rapid, efficacious transdermal treatment, for example, of muscle sprains, erectile dysfunction, or baldness, without requiring the use of needles or other invasive interventions. A topical therapeutic agent and ultrasound energy are applied to a tissue surface, e.g., the skin, such that the ultrasound enhances transdermal penetration of the agent. The invention is especially useful in localized delivery of a controlled dosage of a therapeutic agent to the small blood vessels and capillaries beneath the skin's surface.
(FR)L'invention concerne des traitements et un dispositif permettant de soigner les troubles physiologiques et d'administrer un traitement transdermique rapide et efficace convenant par exemple pour les claquages musculaires, les dysérections ou la calvitie, sans recourir à des aiguilles ou à d'autres interventions invasives. On applique un agent thérapeutique topique et de l'énergie ultrasonique sur une surface de tissu, p. ex. la peau, les ultrasons stimulant la pénétration transdermique de l'agent. L'invention est particulièrement utile pour l'administration localisée d'une dose régulée d'agent thérapeutique dans les petits vaisseaux et les capillaires qui se trouvent sous la surface de la peau.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)