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Machine translation
1. (WO1999039742) LIPOSOME FUSION AND DELIVERY VEHICLE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/039742    International Application No.:    PCT/US1999/002410
Publication Date: 12.08.1999 International Filing Date: 04.02.1999
Chapter 2 Demand Filed:    03.09.1999    
IPC:
A61K 9/127 (2006.01), A61K 48/00 (2006.01), C07K 14/16 (2006.01), C07K 14/785 (2006.01), C12N 15/88 (2006.01)
Applicants: LONGMUIR, Kenneth, J. [US/US]; (US).
WARING, Alan, J. [US/US]; (US).
HAYNES, Sherry, M. [US/US]; (US)
Inventors: LONGMUIR, Kenneth, J.; (US).
WARING, Alan, J.; (US).
HAYNES, Sherry, M.; (US)
Agent: TRECARTIN, Richard, F.; Flehr, Hohbach, Test, Albritton & Herbert LLP Suite 3400 4 Embarcadero Center San Francisco, CA 94111-4187 (US)
Priority Data:
09/019,346 05.02.1998 US
Title (EN) LIPOSOME FUSION AND DELIVERY VEHICLE
(FR) FUSION DE LIPOSOME ET VEHICULE D'ADMINISTRATION
Abstract: front page image
(EN)Described herein are liposome complexes and the individual components thereof for intracellular and/or intranuclear delivery of substances. Methods of use of the provided liposome complexes and components are also described. Generally, the liposome complexes described herein include a non-cationic lipid, a fusogenic peptide and a substance to be delivered to the cell and/or nucleus. In some of the liposome complexes described herein, the fusogenic peptide does not contain multiple positive charges at neutral pH and above. In these liposome complexes, two additional components are used in assembling the liposome complex with DNA.
(FR)L'invention concerne des complexes de liposome et les composants individuels de ceux-ci pour l'administration intracellulaire et/ou intranucléaire de substances. L'invention concerne l'utilisation des techniques d'utilisation de ces complexes de liposome et de ces composants. En général, les complexes de liposome comprennent un lipide non cationique, un peptide fusogénique et une substance à administrer à la cellule et/ou au noyau. Dans certains complexes de liposome, le peptide fusigénique ne contient pas plusieurs charges positives à pH neutre et supérieure. Dans ces complexes de liposome, deux composants supplémentaires sont utilisés pour assembler le complexe de liposome avec l'ADN.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)