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1. (WO1999039207) ACID CLEAVABLE PHENOXYALKYL LINKER FOR COMBINATORIAL SYNTHESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/039207    International Application No.:    PCT/US1999/001370
Publication Date: 05.08.1999 International Filing Date: 21.01.1999
Chapter 2 Demand Filed:    27.08.1999    
IPC:
C07B 61/00 (2006.01), C07C 235/20 (2006.01), C07F 7/18 (2006.01), C07K 1/04 (2006.01)
Applicants: PHARMACOPEIA, INC. [US/US]; P.O. Box CN5350 Princeton, NJ 08543 (US)
Inventors: LI, Ge; (US).
HE, Zhen, Min; (US)
Agent: HANSEN, Philip, E.; Heslin & Rothenberg, P.C. 5 Columbia Circle Albany, NY 12203 (US)
Priority Data:
09/015,282 29.01.1998 US
Title (EN) ACID CLEAVABLE PHENOXYALKYL LINKER FOR COMBINATORIAL SYNTHESIS
(FR) LINKER PHENOXYALKYLE CLIVABLE PAR UN ACIDE POUR SYNTHESE COMBINATOIRE
Abstract: front page image
(EN)A substrate for solid phase synthesis of formula (I) is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of formula (II) wherein n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; R?1¿ is lower alkyl or phenyl; R?2¿ is lower alkyl or phenyl; and R?3¿ is lower alkyl, phenyl or lower alkoxy.
(FR)L'invention porte sur un substrat pour synthèse en phase solide de la formule (I); sur des procédés de préparation du substrat et des intermédiaires utiles. Parmi ces intermédiaires, on trouve des composés de la formule (II) dans laquelle n vaut entre 3 et 20; R représente OH, un ester activé ou les reste d'un support solide ayant une pluralité de fonctionnalités amino; R?1¿ représente alkyle inférieur ou phényle; R?2¿ représente alkyle inférieur ou phényle; et R?3¿ représente alkyle inférieur, phényle ou alcoxy inférieur.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)