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Machine translation
1. (WO1999038998) METHODS OF IDENTIFYING MODULATORS OF KINASES RESPONSIVE TO STRESS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/038998    International Application No.:    PCT/US1999/002065
Publication Date: 05.08.1999 International Filing Date: 27.01.1999
Chapter 2 Demand Filed:    13.08.1999    
IPC:
A61K 31/663 (2006.01), C12N 9/12 (2006.01), G01N 33/50 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065 (US) (For All Designated States Except US).
RESZKA, Alfred, A. [US/US]; (US) (For US Only).
RODAN, Gideon, A. [US/US]; (US) (For US Only)
Inventors: RESZKA, Alfred, A.; (US).
RODAN, Gideon, A.; (US)
Agent: MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065 (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065 (US)
Priority Data:
60/072,940 29.01.1998 US
60/077,582 10.03.1998 US
9807936.1 15.04.1998 GB
60/085,452 14.05.1998 US
9823089.9 21.10.1998 GB
60/106,287 30.10.1998 US
60/108,306 13.11.1998 US
Title (EN) METHODS OF IDENTIFYING MODULATORS OF KINASES RESPONSIVE TO STRESS
(FR) PROCEDES SERVANT A IDENTIFIER DES MODULATEURS DE KINASES SENSIBLES AU STRESS
Abstract: front page image
(EN)The present invention relates to methods of identifying compounds useful as modulators of certain stress responsive kinases. More particularly, the compounds so identified are useful for treating or preventing diseases or conditions that are mediated by, for example, abnormal bone resorption or angiogenesis. These compounds are useful for treating or preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, and tumor growth.
(FR)L'invention concerne des procédés servant à identifier des composés utiles en tant que modulateurs de certaines kinases sensibles au stress. Plus particulièrement, les composés ainsi identifiés sont utiles pour traiter ou prévenir des maladies ou des états provoqués, par exemple, par une résorption osseuse anormale ou par l'angiogenèse. Ces composés sont utiles pour traiter ou prévenir l'ostéoporose et pour inhiber la resténose, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, l'inflammation et la croissance tumorale.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GD, GE, HR, HU, ID, IL, IN, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, SL, TJ, TM, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)