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1. (WO1999038980) TYROSYLPROTEIN SULFOTRANSFERASE POLYPEPTIDES AND POLYNUCLEOTIDES

Pub. No.:    WO/1999/038980    International Application No.:    PCT/US1999/001756
Publication Date: Aug 5, 1999 International Filing Date: Jan 28, 1999
IPC: C07K 14/705
C07K 16/40
C12N 9/10
G01N 33/573
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Inventors: MOORE, Kevin, L.
Title: TYROSYLPROTEIN SULFOTRANSFERASE POLYPEPTIDES AND POLYNUCLEOTIDES
Abstract:
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system.