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1. (WO1999038961) GENE REGULATOR FUSION PROTEINS AND METHODS OF USING THE SAME FOR DETERMINING RESISTANCE OF A PROTEIN TO A DRUG TARGETED THEREAGAINST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/038961    International Application No.:    PCT/US1999/001742
Publication Date: 05.08.1999 International Filing Date: 27.01.1999
Chapter 2 Demand Filed:    25.08.1999    
IPC:
C12Q 1/68 (2006.01)
Applicants: SEPRACOR INC. [US/US]; 111 Locke Drive Marlborough, MA 01752 (US)
Inventors: MELNICK, Laurence, M.; (US).
HEEFNER, Donald, L.; (US)
Agent: CLEMENT, Candice, J.; Heslin & Rothenberg, P.C. 5 Columbia Circle Albany, NY 12203 (US)
Priority Data:
60/073,134 30.01.1998 US
60/093,752 22.07.1998 US
Title (EN) GENE REGULATOR FUSION PROTEINS AND METHODS OF USING THE SAME FOR DETERMINING RESISTANCE OF A PROTEIN TO A DRUG TARGETED THEREAGAINST
(FR) PROTEINES DE FUSION REGULATRICES DE GENES ET LEURS PROCEDES D'UTILISATION POUR DETERMINER LA RESISTANCE D'UNE PROTEINE A UN MEDICAMENT DIRIGE CONTRE ELLE
Abstract: front page image
(EN)Method and gene regulator fusion proteins are disclosed utilizing a bacterial reporter system to quickly and easily identify mutations of a target protein, such as a protease, that confer resistance to a chemotherapeutic agent directed against that target protein.
(FR)L'invention concerne des procédés et des protéines de fusion régulatrices de gènes utilisant un système rapporteur bactérien pour identifier rapidement et facilement les mutations d'une protéine cible, telle qu'une protéase, mutations qui confèrent une certaine résistance à un agent chimiothérapeutique dirigé contre cette protéine cible.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)