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Machine translation
1. (WO1999038849) PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN $g(a)v$g(b)3 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/038849    International Application No.:    PCT/JP1999/000415
Publication Date: 05.08.1999 International Filing Date: 01.02.1999
Chapter 2 Demand Filed:    11.06.1999    
IPC:
C07D 235/30 (2006.01), C07D 239/14 (2006.01), C07D 239/42 (2006.01)
Applicants: MEIJI SEIKA KAISHA, LTD. [JP/JP]; 4-16, Kyobashi 2-chome, Chuo-ku, Tokyo 104-8002 (JP) (For All Designated States Except US).
AJITO, Keiichi [JP/JP]; (JP) (For US Only).
MURAKAMI, Shoichi [JP/JP]; (JP) (For US Only).
ISHIKAWA, Minoru [JP/JP]; (JP) (For US Only).
YAMAMOTO, Mikio [JP/JP]; (JP) (For US Only).
KUBOTA, Dai [JP/JP]; (JP) (For US Only).
GOMI, Shuichi [JP/JP]; (JP) (For US Only).
HACHISU, Mitsugu [JP/JP]; (JP) (For US Only).
KATANO, Kiyoaki [JP/JP]; (JP) (For US Only)
Inventors: AJITO, Keiichi; (JP).
MURAKAMI, Shoichi; (JP).
ISHIKAWA, Minoru; (JP).
YAMAMOTO, Mikio; (JP).
KUBOTA, Dai; (JP).
GOMI, Shuichi; (JP).
HACHISU, Mitsugu; (JP).
KATANO, Kiyoaki; (JP)
Agent: SATO, Kazuo; Kyowa Patent & Law Office, Fuji Building, Room 323, 2-3, Marunouchi 3-chome, Chiyoda-ku, Tokyo 100-0005 (JP)
Priority Data:
10/19282 30.01.1998 JP
Title (EN) PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN $g(a)v$g(b)3 ANTAGONISTS
(FR) DERIVES DE PHENYLPIPERAZINE UTILISES COMME ANTAGONISTES DE L'INTEGRINE $g(a)v$g(b)3
Abstract: front page image
(EN)Compounds represented by general formula (I), pharmaceutically acceptable salts thereof or solvates of the same which have effects of antagonizing integrin $g(a)v$g(b)3, inhibiting human platelet aggregation, etc. wherein A represents a 5- to 7-membered heterocycle, containing two nitrogen atoms, etc.; X and Z represent each CH or N; R?4¿ and R?5¿ represent each alkyl, halogeno, etc.; Q represents $m(g)C=O, $m(g)CH¿2?, etc.; R?6¿ represents H, alkyl, etc.; R?7¿ represents H, alkynyl, etc.; R?8¿ represents H, substituted amino, etc.; R?9¿ represents H or alkyl; m is 0 to 5; n is 0 to 4, p is 2 or 3; and q is 0 or 1.
(FR)Composés de formule générale (I), sels pharmaceutiquement acceptables de ces composés ou solvats de ceux-ci, ayant comme propriété de produire des effets antagonistes sur l'intégrine $g(a)v$g(b)3, d'inhiber l'agrégation plaquettaire humaine, etc, formule dans laquelle A représente un hétérocycle de 5 à 7 chaînons contenant deux atomes d'azote, etc.; X et Z représentent, chacun, CH ou N; R?4¿ et R?5¿ représentent chacun un alkyle, un halogéno, etc.; Q représente $m(g)C=O, $m(g)CH¿2?, etc.; R?6¿ représente un H, un alkyle, etc.; R?7¿ représente un H, un alkynyle, etc.; R?8¿ représente un H, un amino substitué, etc.; R?9¿ représente un H ou un alkyle; m est compris entre 0 et 5; n est compris entre 0 et 4, p est égal à 2 ou 3; et q est égal à 0 ou 1.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)