Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO1999035144) 7-[(PIPERIDIN-1-YL)-PROPOXY]-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1999/035144 International Application No.: PCT/EP1998/008497
Publication Date: 15.07.1999 International Filing Date: 29.12.1998
IPC:
C07D 413/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
Applicants:
FOGUET, Rafael [ES/ES]; ES (UsOnly)
BOLOS, Jordi [ES/ES]; ES (UsOnly)
SACRISTAN, Aurelio [ES/ES]; ES (UsOnly)
CASTELLO, Josep, M. [ES/ES]; ES (UsOnly)
ORTIZ, José, A. [ES/ES]; ES (UsOnly)
FERRER INTERNACIONAL, S.A. [ES/ES]; Gran Via Carlos III, 94 E-08028 Barcelona, ES (AllExceptUS)
Inventors:
FOGUET, Rafael; ES
BOLOS, Jordi; ES
SACRISTAN, Aurelio; ES
CASTELLO, Josep, M.; ES
ORTIZ, José, A.; ES
Agent:
KINZEBACH, Werner @ Reitstötter, Kinzebach & Partner; Postfach 86 06 49 D-81633 München, DE
Priority Data:
970271830.12.1997ES
Title (EN) 7-[(PIPERIDIN-1-YL)-PROPOXY]-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
(FR) DERIVES 7-[(PIPERIDINE-1-YL)-PROPOXY]-CHROMENE-4-ONE, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE
Abstract:
(EN) 7-[3-[4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one derivatives having formula (I) wherein R is hydrogen, CHO, CH2OR2 or COOH; R1 is hydrogen or CH2OH; and R2 is alkyl having 1 to 4 carbon atoms with the proviso that one of substituents R and R1 should be hydrogen, as well as their pharmaceutically acceptable salts. The process for their preparation and the pharmaceutical compositions containing them are also described. The compounds are new and are useful in the treatment of psychosis, schizophrenia and allergy.
(FR) L'invention concerne des dérivés 7-[3-[4-(6-fluorobenzo[d]isoxazol-3-yl(pipéridine-1-yl)-propoxy]-chromène-4-one, de formule (I), dans laquelle R est hydrogène, CHO, CH2OR2 ou COOH; R1 est hydrogène ou CH2OH; et R2 est alkyle renfermant 1 à 4 atomes de carbone, à condition que R ou R1 soit hydrogène; ainsi que leurs sels pharmaceutiquement acceptables. L'invention concerne également un procédé permettant de les préparer et des compositions pharmaceutiques les contenant. Ces composés sont nouveaux et utiles pour le traitement des psychoses, de la schizophrénie et de l'allergie.
front page image
Designated States: AU, BR, CA, CZ, IL, JP, KR, MX, NO, NZ, PL, RO, RU, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)