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1. (WO1999035144) 7-[(PIPERIDIN-1-YL)-PROPOXY]-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE

Pub. No.:    WO/1999/035144    International Application No.:    PCT/EP1998/008497
Publication Date: Fri Jul 16 01:59:59 CEST 1999 International Filing Date: Wed Dec 30 00:59:59 CET 1998
IPC: C07D 413/14
Applicants: FERRER INTERNACIONAL, S.A.
FOGUET, Rafael
BOLOS, Jordi
SACRISTAN, Aurelio
CASTELLO, Josep, M.
ORTIZ, José, A.
Inventors: FOGUET, Rafael
BOLOS, Jordi
SACRISTAN, Aurelio
CASTELLO, Josep, M.
ORTIZ, José, A.
Title: 7-[(PIPERIDIN-1-YL)-PROPOXY]-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
Abstract:
7-[3-[4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one derivatives having formula (I) wherein R is hydrogen, CHO, CH2OR2 or COOH; R1 is hydrogen or CH2OH; and R2 is alkyl having 1 to 4 carbon atoms with the proviso that one of substituents R and R1 should be hydrogen, as well as their pharmaceutically acceptable salts. The process for their preparation and the pharmaceutical compositions containing them are also described. The compounds are new and are useful in the treatment of psychosis, schizophrenia and allergy.