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1. (WO1999034833) DEGRADABLE HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL) ACRYLATES AND GELS AND CONJUGATES DERIVED THEREFROM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1999/034833 International Application No.: PCT/US1999/000594
Publication Date: 15.07.1999 International Filing Date: 06.01.1999
Chapter 2 Demand Filed: 02.08.1999
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
SHEARWATER POLYMERS, INCORPORATED [US/US]; 1112 Church Street Hunstville, AL 35801, US (AllExceptUS)
HARRIS, J., Milton [US/US]; US (UsOnly)
ZHAO, Xuan [CN/US]; US (UsOnly)
Inventors:
HARRIS, J., Milton; US
ZHAO, Xuan; US
Agent:
PEDIGO, Paul, F. ; Alston & Bird LLP P.O. Drawer 34009 Charlotte, NC 28234-4009, US
Priority Data:
60/070,68007.01.1998US
Title (EN) DEGRADABLE HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL) ACRYLATES AND GELS AND CONJUGATES DERIVED THEREFROM
(FR) ACRYLATES DE POLYETHYLENEGLYCOL HETEROBIFONCTIONNEL DEGRADABLES, ET GELS ET CONJUGUES DERIVES DE CES ACRYLATES
Abstract:
(EN) A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.
(FR) L'invention concerne un polyéthylèneglycol hétérobifonctionnel présentant une liaison dégradable par hydrolyse, une première terminaison comprenant un groupe acrylate, et une seconde terminaison comprenant une cible telle qu'une protéine ou un agent pharmaceutique, ou bien une fraction réactive pouvant se lier à une cible. L'invention concerne également la préparation d'hydrogels. Ces hydrogels peuvent être utilisés comme vecteurs pour une protéine ou un agent pharmaceutique qui peut être facilement libéré de façon contrôlée.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1053019JP2003510375 CA2316834AU1999022214DK1053019