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1. WO1999032152 - METHODS FOR DELIVERING PHARMACEUTICAL AGENTS TO MUCOSAL SURFACES

Publication Number WO/1999/032152
Publication Date 01.07.1999
International Application No. PCT/US1998/027410
International Filing Date 23.12.1998
Chapter 2 Demand Filed 14.07.1999
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 9/107 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 47/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/38 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61L 31/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
04Macromolecular materials
06obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
CPC
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61K 9/0065
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
A61K 9/1075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Applicants
  • MDV TECHNOLOGIES, INC. [US]/[US] (AllExceptUS)
  • KHARITONOV, Vladimir [RU]/[US] (UsOnly)
  • RANNEY, Helen, M. [US]/[US] (UsOnly)
  • TREVINO, Leo [US]/[US] (UsOnly)
  • FLORE, Stephen, G. [US]/[US] (UsOnly)
  • DELLAMARY, Luis, A. [MX]/[US] (UsOnly)
  • REEVE, Lorraine, E. [US]/[US] (UsOnly)
  • WEERS, Jeffry, G. [US]/[US] (UsOnly)
Inventors
  • KHARITONOV, Vladimir
  • RANNEY, Helen, M.
  • TREVINO, Leo
  • FLORE, Stephen, G.
  • DELLAMARY, Luis, A.
  • REEVE, Lorraine, E.
  • WEERS, Jeffry, G.
Agents
  • BURKE, John, E.
Priority Data
PCT/US97/2386523.12.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR DELIVERING PHARMACEUTICAL AGENTS TO MUCOSAL SURFACES
(FR) PROCEDES D'ADMINISTRATION D'AGENTS PHARMACEUTIQUES A DES MUQUEUSES
Abstract
(EN) Delivery systems and methods of delivering pharmaceutical agents to a hydrophobic region of an animal, particularly a mucosal surface, such as the mucosal lining of the gastrointestinal (GI) tract, are disclosed. In one embodiment, one or more pharmaceutical agents are incorporated into a delivery system comprising a constitutive polymer, such as a poloxamer, and, optionally, one or more modifier polymers (e.g., carboxymethylcellulose) and/or one or more hydrophilic co-surfactants (e.g., a fatty acid soap). In another embodiment, one or more pharmaceutical agents are incorporated into a delivery system comprising a reverse emulsion, which comprises a disperse polar phase, a continuous lipophilic phase, and one or more emulsifying agents (e.g., a surfactant). The disclosed compositions and methods are useful in the treatment of, for example, gastric $i(H. pylori) infection, where the incorporated pharmaceutical agent is an antibiotic.
(FR) L'invention se rapporte à des systèmes et à des procédés d'administration d'agents pharmaceutiques à une région hydrophobe d'un animal, notamment à une muqueuse, telle que la muqueuse revêtant le tractus gastro-intestinal (GI). Dans une réalisation, on incorpore un ou plusieurs agents pharmaceutiques à un système d'administration comportant un polymère constitutif, tel qu'un poloxamère, et éventuellement, un ou plusieurs polymères modificateurs (par exemple, de la carboxyméthylcellulose) et/ou un ou plusieurs tensioactifs hydrophiles (par exemple, un savon d'acide gras). Dans une autre réalisation, on incorpore un ou plusieurs agents pharmaceutiques à un système d'administration comportant une émulsion inverse, constituée d'une phase polaire dispersée, d'une phase lipophile continue et d'un ou de plusieurs agents émulsifiants (par exemple, un tensioactif). Les compositions et procédés de la présente invention s'avèrent utiles au traitement, par exemple, de l'infection gastrique par $i(H. pylori), l'agent pharmaceutique utilisé étant dans ce cas un antibiotique.
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