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1. WO1999031249 - NUCLEIC ACIDS ENCODING $i(HEV) STRUCTURAL PROTEINS, $i(HEV) STRUCTURAL PROTEINS ENCODED THEREBY AND USES THEREOF

Publication Number WO/1999/031249
Publication Date 24.06.1999
International Application No. PCT/IL1998/000609
International Filing Date 16.12.1998
Chapter 2 Demand Filed 12.07.1999
IPC
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/075 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
075Adenoviridae
CPC
A61K 2039/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12N 2710/10222
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10211Aviadenovirus, e.g. fowl adenovirus A
10222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • ABIC LTD. [IL]/[IL] (AllExceptUS)
  • MICHAEL, Amnon [IL]/[IL] (UsOnly)
  • PITKOVSKI, Jacob [IL]/[IL] (UsOnly)
  • GOLDBERG, Doron [IL]/[IL] (UsOnly)
  • REI KOREN, Ziv [IL]/[IL] (UsOnly)
  • KRISPEL, Simcha [IL]/[IL] (UsOnly)
  • SHMUELI, Eti [IL]/[IL] (UsOnly)
  • MUALEM, Margalit [IL]/[IL] (UsOnly)
  • GUTTER, Bezalel [IL]/[IL] (UsOnly)
  • GALLILI, Gilad [IL]/[IL] (UsOnly)
Inventors
  • MICHAEL, Amnon
  • PITKOVSKI, Jacob
  • GOLDBERG, Doron
  • REI KOREN, Ziv
  • KRISPEL, Simcha
  • SHMUELI, Eti
  • MUALEM, Margalit
  • GUTTER, Bezalel
  • GALLILI, Gilad
Agents
  • LUZZATTO, Kfir
Priority Data
12262616.12.1997IL
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NUCLEIC ACIDS ENCODING $i(HEV) STRUCTURAL PROTEINS, $i(HEV) STRUCTURAL PROTEINS ENCODED THEREBY AND USES THEREOF
(FR) ACIDES NUCLEIQUES CODANT DES PROTEINES STRUCTURALES DU VIRUS DE L'ENTERITE HEMORRAGIQUE DU PORC, PROTEINES STRUCTURALES DU VIRUS DE L'ENTERITE HEMORRAGIQUE AINSI CODEES ET LEUR UTILISATION
Abstract
(EN) Infectious diseases in farm animals are one of the most important economic factors in the poultry industry. One of the principal diseases in birds, is caused by infection with Hemorrhagic Enteritis Virus (HEV), which suppresses the immune system. The present invention relates to nucleic acid molecules encoding structural proteins of Hemorrhagic Enteritis Virus (HEV) which are capable of eliciting in an animal, particularly in birds, protective immunity against HEV. More specifically, the invention relates to nucleic acid sequences which encode the hexon, the penton base or the fiber proteins of HEV. Peptides encoded by the disclosed nucleic acid molecules and any vector or DNA construct comprising them are also within the scope of the invention. A vaccine may comprise as active ingredient a nucleic acid molecule according to the invention, a protein encoded thereby, a DNA construct comprising the nucleic acid molecule, or any mixture of the same.
(FR) Les maladies infectieuses chez les animaux d'élevage constituent un des facteurs économiques les plus importants dans l'industrie avicole. L'une des principales maladies chez les oiseaux est due à une infection provoquée par le virus de l'entérite hémorragique (HEV) qui supprime les réactions immunitaires. La présente invention concerne des molécules d'acide nucléique codant des protéines structurales du virus de l'entérite hémorragique (HEV) pouvant déclencher une réponse immunitaire vis-à-vis du HEV chez un animal, en particulier chez des oiseaux. En particulier, l'invention concerne des séquences d'acide nucléique qui codent la base hexonique, la base pentonique ou les protéines fibreuses du HEV. Les peptides codés par les molécules d'acide nucléique de l'invention et tout vecteur ou ADN de synthèse les comprenant font également l'objet de cette invention. Un vaccin peut comprendre comme principes actifs une molécule d'acide nucléique selon l'invention, une protéine codée par cette molécule, un ADN de synthèse comprenant ladite molécule d'acide nucléique, ou tout mélange de ceux-ci.
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