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1. WO1999029723 - RECOMBINANT NODAVIRUS COMPOSITIONS AND METHODS

Publication Number WO/1999/029723
Publication Date 17.06.1999
International Application No. PCT/US1998/025922
International Filing Date 07.12.1998
Chapter 2 Demand Filed 26.05.1999
IPC
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 47/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 14/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 47/6901
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2770/30022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
30011Nodaviridae
30022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • PENTAMER PHARMACEUTICALS, INC. [US]/[US]
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US]
Inventors
  • HALL, Stephen, G.
Agents
  • CEPURITIS, Talivaldis
Priority Data
08/986,65908.12.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) RECOMBINANT NODAVIRUS COMPOSITIONS AND METHODS
(FR) COMPOSITIONS DE NODAVIRUS RECOMBINES ET METHODES
Abstract
(EN) Recombinant nodavirus related compositions are disclosed. These compositions include chimeric proteins in which a nodavirus capsid protein is present together with a heterologous peptide segment. The heterologous peptide includes at least one cell-specific targeting sequence, such as a B cell epitope, a T cell epitope, or a sequence specific for another cell type, such as a hepatocyte. The chimeric proteins can be assembled to form chimeric virus-like particles. The chimeric virus-like particles are useful in therapeutic applications, such as vaccines and gene-delivery vectors, and in diagnostic applications, such as kits for the testing of body tissue or fluid samples. Methods for the use of recombinant nodavirus related compositions in therapeutic and diagnostic applications are also described.
(FR) L'invention concerne des compositions relatives à des nodavirus recombinés. Ces compositions comprennent des protéines chimères dans lesquelles une protéine de capside de nodavirus est présente avec un segment de peptide hétérologue. Le peptide hétérologue comprend au moins une séquence de ciblage spécifique de cellule, telle qu'un épitope de lymphocytes B, un épitope de lymphocytes T ou une séquence spécifique à un autre type de cellule, telle qu'un hépatocyte. Les protéines chimères peuvent être assemblées pour former des particules de type virus chimères. Les particules de type virus chimères sont utiles dans des applications thérapeutiques, telles que des vaccins et des vecteurs d'apport de gènes, ainsi que dans des applications diagnostiques, telles que des matériels d'analyse d'échantillons de tissus ou de liquides biologiques. Sont également décrites des méthodes d'utilisation de compositions constituées de nodavirus recombinés dans des applications thérapeutiques ou diagnostiques.
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