Processing

Please wait...

Settings

Settings

Goto Application

1. WO1999029676 - PROCESS FOR PREPARING TRIAZOLE COMPOUNDS

Publication Number WO/1999/029676
Publication Date 17.06.1999
International Application No. PCT/EP1998/007482
International Filing Date 20.11.1998
Chapter 2 Demand Filed 09.06.1999
IPC
C07D 521/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
521Heterocyclic compounds containing unspecified hetero rings
CPC
C07D 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 233/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
56with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
C07D 249/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Applicants
  • ZAMBON GROUP S.P.A. [IT]/[IT] (AllExceptUS)
  • VILLA, Marco [IT]/[IT] (UsOnly)
  • BELLI, Aldo [IT]/[IT] (UsOnly)
  • PONZINI, Francesco [IT]/[IT] (UsOnly)
Inventors
  • VILLA, Marco
  • BELLI, Aldo
  • PONZINI, Francesco
Agents
  • LONGONI, Alessandra
Priority Data
MI 97 A 00269805.12.1997EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING TRIAZOLE COMPOUNDS
(FR) PROCEDE DE PREPARATION DE COMPOSES TRIAZOLE
Abstract
(EN) Process for the preparation of a compound of formula (VIII) wherein R1 is Cl, F or CF3; R2 is H, Cl, F or CF3; and R3 is C1-4 alkyl; characterized in that a triol of formula II is treated with a ketone or an aldehyde to give a dioxolane of formula III which by treatment with an aryl-methyl halide gives the compound of formula IV which is hydrolyzed to give a compound of formula V which is functionalized on the primary hydroxy group by a leaving group Lg and treated with a salt of 1,2,4-triazole. The compounds (VIII) is useful for preparing azole derivatives active as antifungal agent.
(FR) L'invention porte sur un procédé de préparation d'un composé de la formule (VIII) dans laquelle R1 représente Cl, F ou CF3; R2 représente H, Cl, F ou CF3; et R3 représente alkyle C1-4. Ce procédé se caractérise en ce qu'un triol de la formule II est traité avec une cétone ou un aldéhyde pour donner un dioxolane de la formule III qui, traité avec un halogénure aryle-méthyle donne le composé de la formule IV qui est hydrolysé pour donner un composé de la formule V fonctionnalisé sur le groupe hydroxy primaire par un groupe labile Lg et traité avec un sel de 1,2,4-triazole. Les composés (VIII) sont utiles dans la préparation de dérivés d'azole agissant comme agents antifongiques.
Related patent documents
US09554191This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
Latest bibliographic data on file with the International Bureau