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1. WO1999029662 - URETHANES, THIO AND DITHIO ANALOGUES, THE SALTS THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE AND METHOD FOR THE PRODUCTION THEREOF

Publication Number WO/1999/029662
Publication Date 17.06.1999
International Application No. PCT/EP1998/007962
International Filing Date 08.12.1998
Chapter 2 Demand Filed 18.03.1999
IPC
C07C 271/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
24with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
C07C 271/56 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
40having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
56with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
C07C 333/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
333Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
02Monothiocarbamic acids; Derivatives thereof
06having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
C07C 333/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
333Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
14Dithiocarbamic acids; Derivatives thereof
18Esters of dithiocarbamic acids
24having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of six-membered aromatic rings
C07D 295/135 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
12substituted by singly or doubly bound nitrogen atoms
135with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
04for urolithiasis
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
Applicants
  • BOEHRINGER INGELHEIM PHARMA KG [DE]/[DE]
Inventors
  • MAIER, Roland
  • MÜLLER, Peter
  • ADELGOSS, Gebhard
  • SCHILCHER, Gebhard
  • HURNAUS, Rudolf
  • MARK, Michael
  • EISELE, Bernhard
Agents
  • LAUDIEN, Dieter
Priority Data
197 54 795.810.12.1997DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) URETHANE, IHRE THIO- UND DITHIOANALOGA, DEREN SALZE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG SOWIE VERFAHREN ZU IHRER HERSTELLUNG
(EN) URETHANES, THIO AND DITHIO ANALOGUES, THE SALTS THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE AND METHOD FOR THE PRODUCTION THEREOF
(FR) URETHANES, LEURS ANALOGUES THIO ET DITHIO, LEURS SELS, MEDICAMENTS CONTENANT CES COMPOSES, LEUR UTILISATION ET LEUR PROCEDE DE PRODUCTION
Abstract
(DE) Die vorliegende Erfindung betrifft Urethane sowie deren Thio- und Dithioanalogen der allgemeinen Formel (I), in der m, n, A, X, Y, und R1 bis R8 wie im Anspruch 1 definiert sind, deren Enantiomere, Diastereomere und deren Salze, insbesondere deren physiologisch verträgliche Säureadditionssalze, welche wertvolle Eigenschaften aufweisen, insbesondere eine inhibitorische Wirkung auf die Cholesterolbiosynthese, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung.
(EN) The present invention relates to urethanes and thio and dithio analogues of general formula (I), wherein m, n, A, X, Y and R1-R8 are as defined in claim 1. The invention also relates to enantiomers, diastereomers and salts thereof, especially physiologically acceptable acid additive salts with valuable properties exhibiting an inhibiting effect on cholesterol biosynthesis, in addition to medicaments containing said compounds, the use thereof and a method for the production thereof.
(FR) La présente invention concerne des uréthanes, ainsi que leurs analogues thio et dithio, correspondant à la formule générale (I), dans laquelle m, n, A, X, Y et les groupes R1 à R8 correspondent à la définition donnée dans la revendication 1, leurs énantiomères, leurs diastéréomères et leurs sels, en particulier, leurs sels d'addition d'acide physiologiquement compatibles, qui présentent de précieuses caractéristiques, en particulier, un effet inhibiteur vis-à-vis de la biosynthèse du cholestérol. L'invention concerne également des médicaments contenant ces composés, leur utilisation et leur procédé de production.
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