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1. (WO1999027105) $i(CHLAMYDIA PNEUMONIAE) GENOMIC SEQUENCE AND POLYPEPTIDES, FRAGMENTS THEREOF AND USES THEREOF, IN PARTICULAR FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INFECTION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1999/027105 International Application No.: PCT/IB1998/001890
Publication Date: 03.06.1999 International Filing Date: 20.11.1998
Chapter 2 Demand Filed: 17.06.1999
IPC:
A61K 39/00 (2006.01) ,C07K 14/295 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
295
from Chlamydiales (O)
Applicants:
GENSET [FR/FR]; 24, rue Royale F-75008 Paris, FR (AllExceptUS)
GRIFFAIS, Rémy [FR/FR]; FR (UsOnly)
HOISETH, Susan, K. [US/US]; US (UsOnly)
ZAGURSKY, Robert, John [US/US]; US (UsOnly)
METCALF, Benjamin, J. [US/US]; US (UsOnly)
PEEK, Joel, A. [US/US]; US (UsOnly)
SANKARAN, Banumathi [IN/US]; US (UsOnly)
FLETCHER, Leah, Diane [US/US]; US (UsOnly)
Inventors:
GRIFFAIS, Rémy; FR
HOISETH, Susan, K.; US
ZAGURSKY, Robert, John; US
METCALF, Benjamin, J.; US
PEEK, Joel, A.; US
SANKARAN, Banumathi; US
FLETCHER, Leah, Diane; US
Agent:
MARTIN, Jean-Jacques; Cabinet Regimbeau 26, avenue Kléber F-75116 Paris, FR
Priority Data:
60/107,07804.11.1998US
97/1467321.11.1997FR
Title (EN) $i(CHLAMYDIA PNEUMONIAE) GENOMIC SEQUENCE AND POLYPEPTIDES, FRAGMENTS THEREOF AND USES THEREOF, IN PARTICULAR FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INFECTION
(FR) SEQUENCE GENOMIQUE ET POLYPEPTIDES DE $i(CHLAMYDIA PNEUMONIAE), LEURS FRAGMENTS ET LEURS UTILISATIONS, EN PARTICULIER POUR LE DIAGNOSTIC, LA PREVENTION OU LE TRAITEMENT D'UNE INFECTION
Abstract:
(EN) The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of $i(Chlamydia pneumoniae), such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the $i(Chlamydia pneumoniae) genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing $i(Chlamydia pneumoniae) infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular $i(Chlamydia pneumoniae), infections.
(FR) L'objet de l'invention est la séquence génomique et les séquences nucléotidiques codant des polypeptides de $i(Chlamydia pneumoniae), tels que des polypeptides d'enveloppe cellulaire, sécrétés ou spécifiques, ou intervenant dans le métabolisme, dans le processus de réplication ou dans la virulence, des polypeptides codés par de telles séquences, ainsi que des vecteurs incluant lesdites séquences et des cellules ou animaux manipulés au moyen desdits vecteurs. L'invention concerne des produits géniques transcriptionnels du génome de $i(Chlamydia pneumoniae), tels que, par exemple, des molécules antisens ou ribozymatiques pouvant être utilisés pour réguler la croissance du micro-organisme. L'invention concerne aussi des procédés de détection desdits acides nucléiques ou polypeptides et des trousses permettant de diagnostiquer une infection à $i(Chlamydia pneumoniae). L'invention concerne en outre un procédé de sélection de composés pouvant moduler une infection bactérienne, et un procédé mettant en oeuvre ces séquences nucléotidiques ou ces polypeptides pour réaliser la biosynthèse ou la biodégradation de molécules d'étude. L'invention concerne enfin des produits pharmaceutiques, en particulier des vaccins, et des compositions servant à la prévention et/ou au traitement d'infections bactériennes, notamment d'infections à $i(Chlamydia pneumoniae).
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020010032336EP1032674EP1854885JP2002536958 CN1279717CA2307846
AU1999011702DK1032674