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1. WO1999026661 - A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA

Publication Number WO/1999/026661
Publication Date 03.06.1999
International Application No. PCT/US1998/024412
International Filing Date 16.11.1998
Chapter 2 Demand Filed 04.06.1999
IPC
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
542Carboxylic acids, e.g. a fatty acid or an amino acid
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • PROTARGA INC. [US]/[US]
Inventors
  • BRADLEY, Matthews, O.
  • SHASHOUA, Victor, E.
  • SWINDELL, Charles, S.
  • WEBB, Nigel, L.
Agents
  • GATES, Edward, R.
Priority Data
08/978,54126.11.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA
(FR) CONJUGAT COVALENT DE CLOZAPINE AVEC UN ACIDE GRAS ET SON UTILISATION POUR TRAITER LA SCHIZOPHRENIE
Abstract
(EN) The invention provides compositions that include conjugates of a fatty acid molecule, preferably $i(cis)-docosahexaenoic acid, and clozapine. The conjugates are useful in treating psychological disorders such as schizophrenia.
(FR) L'invention concerne des compositions qui comprennent des conjugats d'une molécule d'acide gras, de préférence, du cis-docosahéxaénoïque et de la clozapine. Ces conjugats permettent de traiter des troubles psychologiques comme la schizophrénie.
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