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1. WO1999026639 - METHODS FOR MOBILIZING HEMATOPOIETIC FACILITATING CELLS AND HEMATOPOIETIC STEM CELLS INTO THE PERIPHERAL BLOOD

Publication Number WO/1999/026639
Publication Date 03.06.1999
International Application No. PCT/US1998/025368
International Filing Date 24.11.1998
Chapter 2 Demand Filed 24.06.1999
IPC
A61K 35/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
C12N 5/071 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
C12N 5/078 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
C12N 5/0789 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0789Stem cells; Multipotent progenitor cells
A61K 35/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
CPC
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 38/193
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
193Colony stimulating factors [CSF]
C12N 2501/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
22Colony stimulating factors (G-CSF, GM-CSF)
C12N 2501/23
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
C12N 2501/25
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
25Tumour necrosing factors [TNF]
Applicants
  • ALLEGHENY UNIVERSITY OF THE HEALTH SCIENCES [US]/[US]
  • ILDSTAD, Suzanne, T. [US]/[US]
  • ZORINA, Tatiana, D. [US]/[US]
Inventors
  • ILDSTAD, Suzanne, T.
  • ZORINA, Tatiana, D.
Agents
  • CORUZZI, Laura, A.
Priority Data
08/986,51108.12.1997US
09/072,86205.05.1998US
60/066,82126.11.1997US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR MOBILIZING HEMATOPOIETIC FACILITATING CELLS AND HEMATOPOIETIC STEM CELLS INTO THE PERIPHERAL BLOOD
(FR) PROCEDES DE MOBILISATION DE CELLULES FACILITANT L'HEMATOPOIESE ET DE CELLULES SOUCHES HEMATOPOIETIQUES DANS LE SANG PERIPHERIQUE
Abstract
(EN) The present invention relates to methods for mobilizing hematopoietic facilitating cells (FC) and hematopoietic stem cells (HSC) into a subject's peripheral blood (PB). In particular, the invention relates to the activation of both FLT3 and granulocyte-colony stimulating factor (G-CSF) receptor to increase the numbers of FC and HSC in the PB of a donor. The donor's blood contains both mobilized FC and HSC, and can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient. Therefore, PB containing FC and HSC mobilized by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. Alternatively, the donor's hematopoietic tissue, such as bone marrow, can be treated $i(ex vivo) to enrich selectively for FC and HSC populations by activating appropriate cell surface receptors.
(FR) La présente invention concerne des procédés permettant de mobiliser des cellules facilitant l'hématopoïèse ainsi que des cellules souches hématopoïétiques dans le sang périphérique d'un sujet. En particulier, l'invention concerne l'activation du récepteur du facteur stimulant les colonies de granulocytes (G-CSF) et du récepteur FLT3 en vue d'augmenter le nombre de cellules facilitant l'hématopoïèse et de cellules souches hématopoïétiques dans le sang périphérique d'un donneur. Le sang du donneur, qui renferme des cellules facilitant l'hématopoïèse et des cellules souche hématopoïétiques mobilisées, peut être traité et utilisé pour reconstituer le système lymphohématopoïétique d'un receveur. Par conséquent, le sang périphérique renfermant des cellules facilitant l'hématopoïèse et des cellules souches hématopoïétiques mobilisées conformément au procédé de l'invention est utile comme source de cellules du donneur lors d'une greffe de moelle osseuse, dans le cadre du traitement de divers troubles, notamment du cancer, de l'anémie, de l'auto-immunité et de l'immunodéficience. Selon un autre mode de réalisation, les tissus hématopoïétiques du donneur, tels que la moelle osseuse, peuvent être traités $i(ex vivo) de manière à enrichir sélectivement les populations de cellules facilitant l'hématopoïèse et de cellules souches hématopoïétiques par l'activation de récepteurs de surfaces cellulaires appropriés.
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