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1. (WO1999014366) DETECTION OF MINIMAL RESIDUAL DISEASE IN LYMPHOID MALIGNANCIES

Pub. No.:    WO/1999/014366    International Application No.:    PCT/NL1998/000542
Publication Date: Mar 25, 1999 International Filing Date: Sep 18, 1998
IPC: C12Q 1/68
Applicants: ERASMUS UNIVERSITEIT ROTTERDAM
VAN DONGEN, Jacobus, Johannes, Maria
PONGERS-WILLEMSE, Martha, Jacoba
Inventors: VAN DONGEN, Jacobus, Johannes, Maria
PONGERS-WILLEMSE, Martha, Jacoba
Title: DETECTION OF MINIMAL RESIDUAL DISEASE IN LYMPHOID MALIGNANCIES
Abstract:
The invention relates to the field of cancer diagnosis, more specific to the monitoring of disease development during and after treatment. The invention comprises a method for determining minimal residual disease comprising amplifying nucleic acid molecules using at least one primer reactive with a common gene segment and further comprising identifying malignancy-specific nucleic acid sequences by hybridising with a fluorogenic probe specifically and selectively reactive with said malignancy-specific nucleic acid sequences.