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Machine translation
1. (WO1999014353) INTRABODY-MEDIATED CONTROL OF IMMUNE REACTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/014353    International Application No.:    PCT/US1998/019563
Publication Date: 25.03.1999 International Filing Date: 18.09.1998
Chapter 2 Demand Filed:    15.04.1999    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 16/28 (2006.01)
Applicants: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 44 Binney Street Boston, MA 02115 (US) (For All Designated States Except US).
MARASCO, Wayne [US/US]; (US) (For US Only).
MHASHIKAR, Abner [IN/US]; (US) (For US Only)
Inventors: MARASCO, Wayne; (US).
MHASHIKAR, Abner; (US)
Agent: EISENSTEIN, Ronald, I.; Peabody & Brown 101 Federal Street Boston, MA 02110 (US)
Priority Data:
60/059,339 19.09.1997 US
Title (EN) INTRABODY-MEDIATED CONTROL OF IMMUNE REACTIONS
(FR) REGULATION A MEDIATION INTRACORPS DE REACTIONS IMMUNITAIRES.
Abstract: front page image
(EN)The present invention is directed to methods of altering the regulation of the immune system, e.g., by selectively targeting individual or classes of immunomodulatory receptor molecules (IRMs) on cells comprising transducing the cells with an intracellularly expressed antibody, or intrabody, against the IRMs. In a preferred embodiment the intrabody comprises a single chain antibody against an IRM, e.g, MHC-1 molecules.
(FR)La présente invention concerne des procédés d'altération de la régulation du système immunitaire, consistant par exemple, à cibler, de manière sélective, un individu ou des classes de molécules réceptrices immunomodulatrices (IRM) sur des cellules comprenant une transduction de ces cellules avec un anticorps exprimé intracellulairement, ou des anticorps contre les IRM. Selon un mode de réalisation préféré, l'intracorps comprend un anticorps à chaîne unique contre une IRM, par exemple des molécules MHC-1.
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)