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Machine translation
1. (WO1999013090) REGULATION OF PROTEIN SECRETION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/013090    International Application No.:    PCT/GB1998/002664
Publication Date: 18.03.1999 International Filing Date: 04.09.1998
Chapter 2 Demand Filed:    25.03.1999    
IPC:
C07K 14/805 (2006.01), C12N 15/62 (2006.01), C12N 15/85 (2006.01)
Applicants: ROWETT RESEARCH SERVICES LIMITED [GB/GB]; Greenburn Road Bucksburn Aberdeen AB21 9SB (GB) (For All Designated States Except US).
HESKETH, John, Edward [GB/GB]; (GB) (For US Only).
TAULER, Albert [ES/ES]; (ES) (For US Only).
PRYME, Ian, Fraser [GB/NO]; (NO) (For US Only)
Inventors: HESKETH, John, Edward; (GB).
TAULER, Albert; (ES).
PRYME, Ian, Fraser; (NO)
Agent: WHITE, Martin, Paul; Kilburn & Strode 20 Red Lion Street London WC1R 4PJ (GB)
Priority Data:
9718908.8 05.09.1997 GB
Title (EN) REGULATION OF PROTEIN SECRETION
(FR) REGULATION DE LA SECRETION DE PROTEINES
Abstract: front page image
(EN)Mammalian signal peptides can be used to aid in the secretion of mammalian proteins that are normally not secreted. By inactivating signals normally present in the 3' UTRs of mRNAs encoding proteins that are normally not secreted from mammalian cells, the proportion of such mRNA molecules directed to free and cytoskeletal bound polysomes can be reduced.
(FR)La présente invention permet d'utiliser des peptides signaux pour favoriser la sécrétion de protéines mammaliennes qui ne sont normalement pas sécrétées. En effet, en inactivant les signaux normalement présents dans les UTR 3' des ARN messagers codant les protéines qui ne sont normalement pas sécrétées par les cellules mammaliennes, on peut réduire la proportion de telles molécules d'ARN messager ayant pour mission de libérer les polysomes et de s'y lier par le cytosquelette.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)