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1. (WO1999012016) MICROFLUIDIC SYSTEM WITH ELECTROFLUIDIC AND ELECTROTHERMAL CONTROLS

Pub. No.:    WO/1999/012016    International Application No.:    PCT/US1998/017910
Publication Date: Mar 11, 1999 International Filing Date: Aug 27, 1998
IPC: B01L 3/00
G01N 27/447
Applicants: CALIPER TECHNOLOGIES CORPORATION
CHOW, Calvin, Y., H.
KOPF-SILL, Anne, R.
PARCE, J., Wallace
Inventors: CHOW, Calvin, Y., H.
KOPF-SILL, Anne, R.
PARCE, J., Wallace
Title: MICROFLUIDIC SYSTEM WITH ELECTROFLUIDIC AND ELECTROTHERMAL CONTROLS
Abstract:
A method and device for tranporting and/or monitoring a fluid in a multi-port device used in a microfluidic system is provided. The multi-port device includes a substrate comprising a defined channel configuration. A first channel region having a first port and a second port for transporting fluid therebetween is defined in the substrate. A second channel region having a first port and a second port for applying an electric current for heating fluid or for monitoring a fluid parameter therebetween is also defined in the substrate. In some embodiments, the first channel intersects with the second channel. The heating or monitoring aspect of the invention can be used with a variety of biological reactions including polymerase chain reaction and ligase chain reaction.