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1. (WO1999011817) SCREENING METHOD FOR DETERMINING INDIVIDUALS AT RISK OF DEVELOPING DISEASES ASSOCIATED WITH DIFFERENT POLYMORPHIC FORMS OF WILDTYPE P53
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1999/011817    International Application No.:    PCT/CA1998/000828
Publication Date: 11.03.1999 International Filing Date: 31.08.1998
Chapter 2 Demand Filed:    31.03.1999    
IPC:
C12Q 1/68 (2006.01), C12Q 1/70 (2006.01)
Applicants: McGILL UNIVERSITY [CA/CA]; 845 Sherbrooke Street West, Montréal, Québec H3A 1B1 (CA) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
IMPERIAL CANCER RESEARCH TECHNOLOGY (ICRT) [GB/GB]; Sardinia House, Sardinia Street, London WC2A 3NL (GB) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
INTERNATIONAL CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (ICGEB) [IT/IT]; Area Science Park, Padriciano, 99, I-34012 Trieste (IT) (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW only).
MATLASHEWSKI, Greg, J. [CA/CA]; (CA) (For US Only).
BANKS, Lawrence [GB/IT]; (IT) (For US Only).
STOREY, Alan [GB/GB]; (GB) (For US Only)
Inventors: MATLASHEWSKI, Greg, J.; (CA).
BANKS, Lawrence; (IT).
STOREY, Alan; (GB)
Agent: CÔTÉ, France; Swabey Ogilvy Renault, Suite 1600, 1981 McGill College Avenue, Montréal, Québec H3A 2Y3 (CA)
Priority Data:
2,214,461 02.09.1997 CA
Title (EN) SCREENING METHOD FOR DETERMINING INDIVIDUALS AT RISK OF DEVELOPING DISEASES ASSOCIATED WITH DIFFERENT POLYMORPHIC FORMS OF WILDTYPE P53
(FR) PROCEDE DE DEPISTAGE PERMETTANT DE DETERMINER LES SUJETS QUI PRESENTENT UN RISQUE DE DEVELOPPER DES MALADIES ASSOCIEES A DIFFERENTES FORMES POLYMORPHES DE P53 DE TYPE SAUVAGE
Abstract: front page image
(EN)The present invention relates to a screening method to identify individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53; which comprises the steps of: a) obtaining a biological sample from said patients; and b) determining the presence of p53pro or p53arg wildtype alleles in said sample; wherein the allele pattern of patients selected from the group consisting of p53pro/p53pro, p53arg/p53arg and p53pro/p53arg are indicative of a risk factor for developing disease associated with different polymorphic forms of wildtype p53. Notably, individuals who are p53arg/arg are at greater risk of developing pathologies associated with human papillomavirus infections, including cervical cancer.
(FR)La présente invention concerne un procédé de dépistage permettant d'identifier les sujets qui présentent un risque de développer des maladies associées à différentes formes polymorphes de p53 de type sauvage. Le procédé comporte les étapes consistant à: a) obtenir un échantillon biologique provenant desdits patients; et b) déterminer la présence d'allèles de type sauvage de p53pro ou de p53arg dans ledit échantillon; le motif d'allèles sélectionné dans le groupe constitué par p53/pro/p53pro, p53arg/p53arg et p53pro/p53arg indique un facteur de risque de développer une maladie associée à différentes formes polymorphes de p53 de type sauvage. Notamment, des sujets possédant le motif p53arg/p53arg présentent le risque le plus élevé de développer des pathologies associées à des infections dues au papillomavirus humain, dont le cancer du col utérin.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, HR, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)